Journal article
Improvements in Distal Lung Function Correlate With Asthma Symptoms After Treatment With Oral Montelukast
Chest, v 130(6), pp 1726-1732
01 Dec 2006
PMID: 17166989
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The distal airways are likely to contribute to asthma pathobiology and symptoms but have rarely been specifically evaluated in relation to systemic oral therapy. We hypothesized that treatment with montelukast, an oral cysteinyl-leukotriene receptor antagonist, would improve both proximal and distal lung physiology in patients with mild asthma.
Randomized, double-blind, crossover design.
Academic referral center.
Subjects with mild asthma limited to using short-acting inhaled β2-agonists.
Nineteen subjects with mild asthma underwent a baseline assessment of lung function, lung mechanics, and symptoms, followed by randomization to therapy with montelukast, 10 mg taken in the evening, or placebo in a crossover, double-blind fashion. Each treatment phase lasted 4 weeks, with a 2-week washout period. A repeat evaluation was performed during the last week of each treatment phase.
Montelukast resulted in improvement in (mean ± SD) proximal and distal lung function parameters (change in FEV1: montelukast, 0.16 ± 0.06 L; placebo, −0.05 ± 0.05 L; p = 0.008); change in specific conductance: montelukast, 7.2 ± 2.9% predicted; placebo, −17 ± 8% predicted; p = 0.007; change in % predicted residual volume [RV]: montelukast, 18.4 ± 8.3% predicted; placebo, 3.0 ± 2.9% predicted; p = 0.05). Improvement in symptoms (ie, wheeze and chest tightness) correlated with improvements in RV while receiving montelukast, but not while receiving placebo (Pearson coefficients: 0.55 and 0.66, respectively; p < 0.008 and 0.04, respectively).
The systemically acting oral agent montelukast improves proximal and distal lung physiology. Improvements in distal lung function correlate with improvements in asthma symptoms.
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Details
- Title
- Improvements in Distal Lung Function Correlate With Asthma Symptoms After Treatment With Oral Montelukast
- Creators
- Monica Kraft - Duke Medical CenterCharles B. Cairns - Duke Medical CenterMisoo C. Ellison - National Jewish HealthJuno Pak - National Jewish HealthCharles Irvin - University of Vermont Medical CenterSally Wenzel - National Jewish Health
- Publication Details
- Chest, v 130(6), pp 1726-1732
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000242876200019
- Scopus ID
- 2-s2.0-33749435086
- Other Identifier
- 991021448186504721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Critical Care Medicine
- Respiratory System