Journal article
Improvements in Patient-Reported Outcomes Through Six Months of Guselkumab Treatment in Patients With Active Psoriatic Arthritis: Real-World Data From the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry
ACR open rheumatology, v 6(5), pp 304-311
01 May 2024
PMID: 38417434
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. Evaluate patient-reported outcomes after 6 months of on-label guselkumab use in patients with rheumatologist-diagnosed active psoriatic arthritis (PsA) enrolled in the CorEvitas PsA/Spondyloarthritis Registry. Methods. This analysis includes registry participants who initiated and persisted with on-label guselkumab (after US Food and Drug Administration approval for PsA; 100 mg at weeks 0, 4, and every 8 weeks) at their 6-month follow-up visit (On-Label Persisters). Among patients not meeting response criteria at baseline, responses at 6 months were determined for patient-reported outcomes, including patient-reported pain (0-100 mm visual analog scale), patient global assessment of arthritis + psoriasis (PtGA; 0-100 visual analog scale), and Health Assessment Questionnaire-Disability Index (HAQ-DI; 0-3). Unadjusted, nominal P values were calculated via single-proportion, one-sided test (H-0 = 0%; alpha = 0.05). Results. Of 90 On-Label Persisters, most had treatment-resistant PsA (92.2% and 73.3% previously received >= 1 and >= 2 biologic/targeted synthetic disease-modifying antirheumatic drugs, respectively), with mean (SD) baseline patient-reported pain, PtGA, and HAQ-DI scores of 57.0 (24.6), 50.3 (24.4), and 0.9 (0.6), respectively. Among those with patient-reported pain and PtGA scores of at least 15 at baseline, 40.2% (33/82) and 46.8% (36/77), respectively, achieved at least 15-mm reductions at 6 months; among those with HAQ-DI scores of at least 0.35 and more than 0.5 at baseline, respectively, 30.4% (21/69) achieved improvements of at least 0.35 and 10.3% (6/58) achieved scores of 0.5 or lower at 6 months (all nominal P < 0.001). Conclusion. Pain and physical function are important contributors to health-related quality of life. In this real-world population of patients with treatment-resistant PsA and 6 months of persistent guselkumab treatment, clinically meaningful improvements in pain and physical function were achieved by approximately 40% and 30% of patients, respectively.
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Details
- Title
- Improvements in Patient-Reported Outcomes Through Six Months of Guselkumab Treatment in Patients With Active Psoriatic Arthritis: Real-World Data From the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry
- Creators
- Philip J. Mease - Providence CollegeAlexis Ogdie - University of PennsylvaniaJohn Tesser - Arthritis and Rheumatism AssociatesNatalie J. Shiff - JanssenRuizhi Sophia Zhao - JanssenSoumya D. Chakravarty - Drexel UniversityMichael Kelleman - Navitas SystemsRhiannon Dodge - Navitas SystemsRobert R. McLean - Navitas SystemsAaron Broadwell - Rheumatol & Osteoporosis Specialists, Shreveport, LA USAArthur Kavanaugh - University of California, San DiegoJoseph F. Merola - The University of Texas Southwestern Medical Center
- Publication Details
- ACR open rheumatology, v 6(5), pp 304-311
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Janssen Scientific Affairs, LLC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Rheumatology; General Internal Medicine
- Web of Science ID
- WOS:001176667100001
- Scopus ID
- 2-s2.0-85186615663
- Other Identifier
- 991021930318104721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology