Journal article
Improving prediction of sudden unexpected death in epilepsy: From SUDEP-7 to SUDEP-3
Epilepsia (Copenhagen), v 62(7), pp 1536-1545
Jul 2021
PMID: 34086290
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sudden unexpected death in epilepsy (SUDEP) is a significant cause of mortality in epilepsy. The aim of this study is to evaluate the validity of the SUDEP-7 inventory and its components as tools for predicting SUDEP risk, and to develop and validate an improved inventory.
The study included 28 patients who underwent video-electroencephalography (EEG) monitoring and later died of SUDEP, and 56 age- and sex-matched control patients with epilepsy. The SUDEP-7 score, its individual components, and an alternative inventory were examined as predictors of SUDEP.
SUDEP-7 scores were significantly higher among SUDEP patients compared with controls, both at time of admission (p = 0.024) and most recent follow-up (p = 0.016). SUDEP-7 scores declined only among controls, who demonstrated reduced seizure frequency. Seizure freedom after epilepsy surgery was also associated with survival. Several components of the SUDEP-7 inventory were independently associated with higher risk of SUDEP, including more than three generalized tonic-clonic (GTC) seizures (p = 0.002), one or more GTC seizures (p = 0.001), or one or more seizures of any type within the last year (p = 0.013), and intellectual disability (p = 0.031). In stepwise regression models, SUDEP-7 scores did not enhance the prediction of SUDEP over either GTC seizure frequency or seizure frequency alone. A novel SUDEP-3 inventory comprising GTC seizure frequency, seizure frequency, and intellectual disability (p < 0.001) outperformed the SUDEP-7 inventory (p = 0.010) in predicting SUDEP.
Our findings demonstrate the limitations of the SUDEP-7 inventory. We propose a new three-item SUDEP-3 inventory, which predicts SUDEP better than the SUDEP-7.
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Details
- Title
- Improving prediction of sudden unexpected death in epilepsy: From SUDEP-7 to SUDEP-3
- Creators
- Roozbeh Tarighati Rasekhi - Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA, USAKathryn N Devlin - Drexel UniversityJoely A Mass - Thomas Jefferson UniversityMustafa Donmez - Memorial Medical CenterBurcu Asma - Department of Neurology, Tepecik Training and Research Hospital, Izmir, Turkey.Michael R Sperling - Thomas Jefferson University HospitalMaromi Nei - Thomas Jefferson University Hospital
- Publication Details
- Epilepsia (Copenhagen), v 62(7), pp 1536-1545
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000657859100001
- Scopus ID
- 2-s2.0-85107116821
- Other Identifier
- 991019169667204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology