Journal article
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Eiastomeric Tissue-Engineered Heart Valves
JACC. Basic to translational science, v 5(12), pp 1187-1206
01 Dec 2020
PMID: 33426376
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the tong-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.
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Details
- Title
- In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Eiastomeric Tissue-Engineered Heart Valves
- Creators
- Marcelle Uiterwijk - University of AmsterdamAnthal I. P. M. Smits - Eindhoven University of TechnologyDaphne van Geemen - Eindhoven University of TechnologyBas van Klarenbosch - University Medical Center UtrechtSylvia Dekker - Eindhoven University of TechnologyMaarten Jan Cramer - University Medical Center UtrechtJan Willem van Rijswijk - University of AmsterdamEmily B. Lurier - Eindhoven University of TechnologyAndrea Di Luca - Eindhoven University of TechnologyMarieke C. P. Brugmans - Xeltis BV, Eindhoven, NetherlandsTristan Mes - SupraPolix (Netherlands)Anton W. Bosman - SupraPolix (Netherlands)Elena Aikawa - Brigham and Women's HospitalPaul F. Grundeman - University Medical Center UtrechtCarlijn V. C. Bouten - Eindhoven University of TechnologyJolanda Kluin - Eindhoven University of TechnologySarah S Long - Pediatrics
- Publication Details
- JACC. Basic to translational science, v 5(12), pp 1187-1206
- Publisher
- Elsevier
- Number of pages
- 20
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000604568500004
- Scopus ID
- 2-s2.0-85097461379
- Other Identifier
- 991019353628104721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems