Journal article
In Vitro Release of Colchicine Using Poly(phosphazenes): The Development of Delivery Systems for Musculoskeletal Use
Pharmaceutical development and technology, v 3(1)
1998
PMID: 9532600
Abstract
ABSTRACT
A colchicine release system utilizing biodegradable poly (phosphazenes) was investigated in vitro for intra-articular administration. Polymer degradation and drug release studies were performed on colchicine-loaded poly (phosphazenes) containing either imidazotyl (I-PPHOS) or ethyl gtycinato (EG-PPHOS) side chain substituents over a 21-day period. To study the effects of an implantable colchi-cine-PPHOS delivery system on local musculoskeletal tissue in vitro, osteoblast-like cells were grown on the matrices. Colchicine release was 20% for I-PPHOS and 60% for EG-PPHOS over the 21-day period. Release appeared to proceed through a combination of diffusional and degradative mechanisms. Environmental scanning electron microscopy (ESEM) studies revealed large pores in the drug-depleted devices in contrast to the control matrices without drug, which may have contributed to the release seen, especially with ethyl glycinato-containing matrices. Cell growth on matrices containing colchicine was significantly (p < 0.05) inhibited in contrast to growth on tissue culture polystyrene (TCPS) and EG-PPHOS matrices without drug. The in vitro cell kinetic data suggest that designs for in vivo studies must take into account possible toxicity of colchicine and the polymer matrix on local tissue. Biodegradable PPHOS systems are promising candidates for use as intra-articular delivery vehicles for drugs with potential for systemic toxicity.
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26 citations in Scopus
Details
- Title
- In Vitro Release of Colchicine Using Poly(phosphazenes): The Development of Delivery Systems for Musculoskeletal Use
- Creators
- Sobrasua M. Ibim - Morris Brown CollegeSaadiq F. El-Amin - Massachusetts Institute of TechnologyMary E. P. Goad - NeuroDevelopment CenterArchel M. A. Ambrosio - Massachusetts Institute of TechnologyHarry R. Allcock - Pennsylvania State UniversityCato T. Laurencin - Massachusetts Institute of Technology
- Publication Details
- Pharmaceutical development and technology, v 3(1)
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Scopus ID
- 2-s2.0-0031777551
- Other Identifier
- 991019339571104721