Physiological Effects and Microbial Susceptibility
A total of 132 strains of anaerobic bacteria were tested for susceptibility to josamycin, using a broth dilution technique. All strains of
Peptococcus
species,
Peptostreptococcus
species, and
Bacteroides fragilis
were inhibited by 2 μg or less per ml. Seventy percent of these susceptible strains were also killed by 2 μg or less of josamycin per ml. However, 2 of 12
Clostridium
species and 6 of 10
Fusobacterium
species had minimum inhibitory concentrations of 32 μg or more per ml.