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In Young Infertile Women Low Serum Anti-Müllerian Hormone is Not a Good Predictor of Ongoing Clinical Pregnancy Rate [36A]
Journal article   Peer reviewed

In Young Infertile Women Low Serum Anti-Müllerian Hormone is Not a Good Predictor of Ongoing Clinical Pregnancy Rate [36A]

Selena Park, Deanna Brasile, William Dampier and Karen Berkowitz
Obstetrics and gynecology (New York. 1953), v 133 Suppl 1(1), pp 19S-19S
May 2019
DOI: https://doi.org/10.1097/01.AOG.0000559383.28109.c1

Abstract

INTRODUCTION:Age and serum anti-müllerian hormone (AMH) levels strongly influence treatment decisions in infertile women. We compared ongoing clinical pregnancy rates (PR) in younger (<35) versus older (> or =35) infertile women with AMH levels of <1.0 or > or =1.0 undergoing controlled ovarian hyperstimulation (COH). METHODS:Included142 infertile women aged 30-45 at a private practice from 2014-2018. Patients were stratified by age and serum AMH. Recordedserum estradiol, follicle-stimulating hormone, AMH, age, race, BMI, number of COH cycles, medication quantities. Excludedwomen with ovulatory dysfunction, PCOS, ovarian surgery, smoking, autoimmune disease, FSH levels of >40. Ongoing clinical pregnancylive intrauterine gestation of > or =8 weeks by pelvic ultrasound. RESULTS:Ongoing clinical PR was different in women with AMH <1.0 when stratified by age (P<.05). Nine younger women undergoing 5 or more COH cycles attained an ongoing clinical pregnancy, while in older women, ongoing clinical PR was 50% (95% CI 36-63, N 16). In contrast, women with AMH > or =1.0 showed no difference in ongoing clinical PR when stratified by age, with PR of 69% in younger (95% CI 62-74, N 37) and 64% in older women (95% CI 58-70, N 25) after 4 COH cycles. CONCLUSION:We demonstrated as a proof of principle that age is a better predictor of ongoing PR than serum AMH when values are <1.0. This suggests that age is a more clinically useful parameter than AMH when counseling younger infertile women undergoing COH stimulation about their probability of ongoing clinical PR.

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Obstetrics & Gynecology
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