Journal article
In situ apatite forming injectable hydrogel
Journal of biomedical materials research. Part A, v 83(1), pp 249-256
Oct 2007
PMID: 17647227
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Injectable polymers are attractive materials for tissue augmentation or replacement. Thermosensitive hydrogels, especially poly(N-isopropylacryamide), have been investigated for these applications to exploit the lower critical solution temperature (LCST) which falls between room and body temperatures. Some practical limitations to the material are the load-bearing capabilities and the ability to bond to the host tissue. In this work, we evaluated a novel, injectable apatite-forming material system: poly(N-isopropylacryamide)-co-poly(ethyleneglycol) dimethacrylate, with the addition of tri-methacryloxypropyltrimethoxysilane (MPS). We have previously reported that MPS concentration permits the material system to be tuned to different compressive moduli ranging from 50-700 kPa without altering the LCST of the material. Here, we explore the apatite formation of this material system in protein-free and protein-containing SBF. The MPS-containing hydrogel system exhibited apatite formation throughout the gel thickness. The apatite formation was inhibited by the presence of proteins. This mechanism is likely controlled by the silanol groups (Si-OH) in MPS, which provided attachment sites for calcium and initiated mineral dissolution from the simulated biological environments. The challenge of this material system is to balance the network-forming and modulus-enhancing MPS while maintaining an injectable hydrogel for potential tissue regeneration.
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Details
- Title
- In situ apatite forming injectable hydrogel
- Creators
- Emily Ho - Department of Materials Science and Engineering, College of Engineering, Drexel University,3201 Chestnut Street, Philadelphia, Pennsylvania 19104,USAAnthony LowmanMichele Marcolongo
- Publication Details
- Journal of biomedical materials research. Part A, v 83(1), pp 249-256
- Publisher
- Wiley; United States
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000249387300029
- Scopus ID
- 2-s2.0-34548770125
- Other Identifier
- 991014877893004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials