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In situ encapsulation of horseradish peroxidase in electrospun porous silica fibers for potential biosensor applications
Journal article   Peer reviewed

In situ encapsulation of horseradish peroxidase in electrospun porous silica fibers for potential biosensor applications

Alpa C Patel, Shuxi Li, Jian-Min Yuan and Yen Wei
Nano letters, v 6(5), pp 1042-1046
May 2006
DOI: https://doi.org/10.1021/nl0604560
PMID: 16683848
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Biosensing Techniques - instrumentation Electrochemistry Enzymes, Immobilized Horseradish Peroxidase Silicon Dioxide
Nanoporous silica nanofibers have been employed as a matrix to encapsulate horseradish peroxide enzymes via a simple electrospinning method. A viscous solution of prehydrolyzed tetramethyl orthosilicate, beta-d-glucose, poly(vinyl alcohol), and enzymes were employed as spinning solution to generate porous fibers in the form of nonwoven mats. The silica fiber mats thus produced have a high surface area because of the small diameter (100 to 200 nm) of the fibers as well as the extreme porosity (2 to 4 nm) of individual fibers caused by the glucose template present in them. The high surface area, mechanical flexibility, thermal stability, reusability, and freedom of encapsulating various enzymes make porous silica nanofibers excellent biosensors.

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194 citations in Web of Science
210 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Web of Science research areas
Chemistry, Multidisciplinary
Chemistry, Physical
Materials Science, Multidisciplinary
Nanoscience & Nanotechnology
Physics, Applied
Physics, Condensed Matter
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