Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
In situ fibril stretch and sliding is location-dependent in mouse supraspinatus tendons
Journal of biomechanics, v 47(16), pp 3794-3798
18 Dec 2014
PMID: 25468300
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tendons are able to transmit high loads efficiently due to their finely optimized hierarchical collagen structure. Two mechanisms by which tendons respond to load are collagen fibril sliding and deformation (stretch). Although many studies have demonstrated that regional variations in tendon structure, composition, and organization contribute to the full tendon's mechanical response, the location-dependent response to loading at the fibril level has not been investigated. In addition, the instantaneous response of fibrils to loading, which is clinically relevant for repetitive stretch or fatigue injuries, has also not been studied. Therefore, the purpose of this study was to quantify the instantaneous response of collagen fibrils throughout a mechanical loading protocol, both in the insertion site and in the midsubstance of the mouse supraspinatus tendon. Utilizing a novel atomic force microscopy-based imaging technique, tendons at various strain levels were directly visualized and analyzed for changes in fibril d-period with increasing tendon strain. At the insertion site, d-period significantly increased from 0% to 1% tendon strain, increased again from 3% to 5% strain, and decreased after 5% strain. At the midsubstance, d-period increased from 0% to 1% strain and then decreased after 7% strain. In addition, fibril d-period heterogeneity (fibril sliding) was present, primarily at 3% strain with a large majority occurring in the tendon midsubstance. This study builds upon previous work by adding information on the instantaneous and regional-dependent fibrillar response to mechanical loading and presents data proposing that collagen fibril sliding and stretch are directly related to tissue organization and function. (C) 2014 Elsevier Ltd. All rights reserved.
Metrics
Details
- Title
- In situ fibril stretch and sliding is location-dependent in mouse supraspinatus tendons
- Creators
- Brianne K. Connizzo - University of PennsylvaniaJoseph J. Sarver - Drexel UniversityLin Han - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USALouis J. Soslowsky - University of Pennsylvania
- Publication Details
- Journal of biomechanics, v 47(16), pp 3794-3798
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- P30 AR050950 / Penn Center for Musculoskeletal Disorders (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32-AR007132 / NIH/NIAMS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) Faculty Start-up Grant at Drexel University P30AR050950 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000347864900002
- Scopus ID
- 2-s2.0-84920677399
- Other Identifier
- 991019169652304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical