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Journal article
In the Wrong Place with the Wrong SNP The Association Between Stressful Neighborhoods and Cardiac Arrest Within Beta-2-adrenergic Receptor Variants
Epidemiology (Cambridge, Mass.), v 27(5), pp 656-662
01 Sep 2016
PMID: 27153462
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Abstract
Background: Sudden cardiac arrest has been linked independently both to stressful neighborhood conditions and to polymorphisms in the ADRB2 gene. The ADRB2 gene mediates sympathetic activation in response to stress. Therefore, if neighborhood conditions cause cardiac arrest through the stress pathway, the ADRB2 variant may modify the association between neighborhood conditions, such as socioeconomic deprivation and incidence of cardiac arrest. Methods: The Cardiac Arrest Blood Study Repository is a population-based repository of specimens and other data from adult cardiac arrest patients residing in King County, Washington. Cases (n = 1,539) were 25-to 100-year-old individuals of European descent who experienced out-of-hospital cardiac arrest from 1988 to 2004. Interactions between neighborhood conditions and the ADRB2 genotype on cardiac arrest risk were assessed in a case-only study design. Gene-environment independence was assessed in blood samples obtained from King County residents initially contacted by randomdigit dialing. Results: Fewer than 4% of study subjects resided in socioeconomically deprived neighborhoods. Nonetheless, the case-only analysis indicated the presence of supramultiplicative interaction of socioeconomic deprivation and the homozygous Gln27Glu variant (caseonly odds ratio: 1.8 [95% confidence interval: 1.0, 2.9]). Interactions between population density and the homozygous Gln27Glu variant were weaker (case-only odds ratio: 1.2 [95% confidence interval: 0.97, 1.5]). Conclusions: Findings support a supramultiplicative interaction between the Gln27Glu ADRB2 variant and socioeconomic deprivation among individuals of European descent. This result is consistent with the hypothesis that the elevation in cardiac arrest risk associated with socioeconomic deprivation operates through the stress pathway.
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- Title
- In the Wrong Place with the Wrong SNP The Association Between Stressful Neighborhoods and Cardiac Arrest Within Beta-2-adrenergic Receptor Variants
- Creators
- Stephen J. Mooney - University of California, San FranciscoStephanie T. Grady - Columbia UniversityNona Sotoodehnia - University of WashingtonRozenn N. Lemaitre - University of WashingtonErin R. Wallace - Seattle Childrens Res Inst, Seattle, WA USAApril F. Mohanty - VA Salt Lake City Hlth Care Syst, IDEAS Ctr, Salt Lake City, UT USAJean Yee - University of WashingtonDavid S. Siscovick - College Station Medical CenterThomas D. Rea - University of WashingtonBarbara McKnight - University of WashingtonPui-Yan Kwok - Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA USAAngel C. Y. Mak - Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA USAStephanie Hesselson - College Station Medical CenterGina S. Lovasi - Columbia University
- Publication Details
- Epidemiology (Cambridge, Mass.), v 27(5), pp 656-662
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- T32CA009529 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P30 DK035816 / UW Nutrition and Obesity Research Center EHE International Mailman School of Public Health, Columbia University P30DK035816 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) RO1-HL091244; RO1-HL092111; RO1-HL088456 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01HL092111; R01HL088456; R01HL091244 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) K01HD067390 / National Institute for Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) T32-CA09529 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) K01HD067390 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000381011000013
- Scopus ID
- 2-s2.0-84965078909
- Other Identifier
- 991020099389004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health