Journal article
In vitro incorporation of fucose and methionine into human platelet proteins
Biochemical and biophysical research communications, v 109(4), pp 1256-1263
1982
PMID: 7168764
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human blood platelets, maintained
in
vitro
, incorporate labelled methionine into a variety of high molecular weight proteins and labelled fucose into a different set of glycoproteins. The incorporation of methionine is completely sensitive to cycloheximide and partially sensitive to chloramphenicol and leucovorin demonstrating
de
novo
synthesis. The incorporation of fucose is insensitive to these inhibitors but inhibited by 6-thioguanine which would indicate that a fucosyl transferase is adding the sugar onto pre-existing glycoproteins. Some of the fucosyl-glycoproteins correspond to surface glycoproteins.
Metrics
Details
- Title
- In vitro incorporation of fucose and methionine into human platelet proteins
- Creators
- Gerald Soslau - H.L. Orlowitz Cancer Institute, Hahnemann Medical School, Philadelphia, PA 19102 USAAnne Rybicki - The Department of Biochemistry, Hahnemann Medical School, Philadelphia, PA 19102 USA
- Publication Details
- Biochemical and biophysical research communications, v 109(4), pp 1256-1263
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1982PX66200027
- Scopus ID
- 2-s2.0-0020308765
- Other Identifier
- 991019183955904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics