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Journal article
In-vitro stress relaxation response of neonatal peripheral nerves
Journal of biomechanics, v 128, 110702
09 Nov 2021
PMID: 34479117
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Characterizing the viscoelastic behavior of neonatal peripheral nerves is critical in understanding stretch-related peripheral nerve injuries (PNIs) in neonates. This study investigated the in-vitro viscoelastic stress relaxation response of neonatal piglet brachial plexus (BP) and tibial nerves at two different strain levels (10% and 20%) and stress relaxation testing durations (90- and 300-seconds). BP and tibial nerves from 20 neonatal piglets were harvested and pre-stretched to either 10% or 20% strain at a dynamic rate of 100 mm/min to simulate conditions, such as shoulder dystocia, that may lead to stretch-related PNIs in neonates. At constant strain, the reduction in stress was recorded for 90- or 300-seconds. The biomechanical data were then fit to a viscoelastic model to acquire the short- and long-term stress relaxation time-constants. Though no significant differences in the degree of stress relaxation were found between the two tested strain levels after 90 seconds in both nerve types, reduction in stress was moderately greater (p = 0.056) at 10% strain than at 20% for BP after 300 seconds. The reduction in stress was significantly higher in nerves subjected to a 300 second testing duration than 90 second for both strain levels and nerve types. When comparing BP and tibial nerve stress relaxation response, BP nerve relaxed significantly more than tibial at both strain levels after 90 seconds, but no significant differences were observed after 300 seconds. Our results confirm that neonatal peripheral nerve tissue is highly viscoelastic. These novel biomechanical data can be incorporated into finite element and computational models studying neonatal PNIs.
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Details
- Title
- In-vitro stress relaxation response of neonatal peripheral nerves
- Creators
- Tanmay Majmudar - Drexel UniversitySriram Balasubramanian - Drexel UniversityRachel Magee - Drexel UniversityBernard Gonik - Wayne State UniversityAnita Singh - Widener University
- Publication Details
- Journal of biomechanics, v 128, 110702
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- 1752513 / NSF CAREER; National Science Foundation (NSF); NSF - Office of the Director (OD) R15HD093024 / Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000704362200005
- Scopus ID
- 2-s2.0-85113938028
- Other Identifier
- 991019167432604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical