Journal article
In vivo acceleration of heart relaxation performance by parvalbumin gene delivery
The Journal of clinical investigation, v 107(2), 191
01 Jan 2001
PMID: 11160135
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Defective cardiac muscle relaxation plays a causal role in heart failure. Shown here is the new in vivo application of parvalbumin, a calcium-binding protein that facilitates ultrafast relaxation of specialized skeletal muscles. Parvalbumin is not naturally expressed in the heart. We show that parvalbumin gene transfer to the heart in vivo produces levels of parvalbumin characteristic of fast skeletal muscles, causes a physiologically relevant acceleration of heart relaxation performance in normal hearts, and enhances relaxation performance in an animal model of slowed cardiac muscle relaxation. Parvalbumin may offer the unique potential to correct defective relaxation in energetically compromised failing hearts because the relaxation-enhancement effect of parvalbumin arises from an ATP-independent mechanism. Additionally, parvalbumin gene transfer may provide a new therapeutic approach to correct cellular disturbances in calcium signaling pathways that cause abnormal growth or damage in the heart or other organs.
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Details
- Title
- In vivo acceleration of heart relaxation performance by parvalbumin gene delivery
- Creators
- Michael L. Szatkowski - University of MichiganMargaret V. Westfall - University of MichiganCarlen A. Gomez - University of MichiganPhilip A. Wahr - University of MichiganDaniel E. Michele - University of MichiganChristiana DelloRusso - University of MichiganImmanuel I. Turner - University of MichiganKatie E. Hong - University of MichiganFaris P. Albayya - University of MichiganJoseph M. Metzger - University of Michigan
- Publication Details
- The Journal of clinical investigation, v 107(2), 191
- Publisher
- American Society for Clinical Investigation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000166457900010
- Scopus ID
- 2-s2.0-0035142395
- Other Identifier
- 991021838690104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental