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Journal article
In vivo biocompatibility and degradability of a Zn-Mg-Fe alloy osteosynthesis system
Bioactive materials, v 7, pp 154-166
01 Jan 2022
PMID: 34466724
Abstract
Zinc is generally considered to be one of the most promising materials to be used in biodegradable implants, and many zinc alloys have been optimized to improve implant biocompatibility, degradation, and mechanical properties. However, long-term degradation leads to the prolonged presence of degradation products, which risks foreign body reactions. Herein, we investigated the in vivo biocompatibility and degradation of a biodegradable Zn-Mg-Fe alloy osteosynthesis system in the frontal bone, mandible, and femur in beagles for 1 year. Results of the routine blood, biochemical, trace element, and histological analyses of multiple organs, peripheral blood CD4/CD8a levels, and serum interleukin 2 and 4 levels showed good biocompatibility of the Zn-Mg-Fe alloy. Zinc content analysis revealed zinc accumulation in adjacent bone tissue, but not in the liver, kidney, and spleen, which was related to the degradation of the Zn-Mg-Fe alloy. The alloy demonstrated a uniform slowing degradation rate in vivo. No degradation differences in the frontal bone, mandible, and femur were observed. The degradation products included zinc oxide [ZnO], zinc hydroxide [Zn(OH)(2)], hydrozincite [Zn-5(OH)(6)(CO3)(2)], and hopeite [Zn-3(PO4)(2)center dot 4H(2)O]. The good biocompatibility and degradation properties of the Zn-Mg-Fe alloy render it a very attractive osteosynthesis system for clinical applications.
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Details
- Title
- In vivo biocompatibility and degradability of a Zn-Mg-Fe alloy osteosynthesis system
- Creators
- Xiaoxi Shao - Air Force Medical UniversityXiang Wang - Air Force Medical UniversityFangfang Xu - Air Force Medical UniversityTaiqiang Dai - Air Force Medical UniversityJack G. Zhou - Drexel University, Mechanical Engineering and MechanicsJiang Liu - College Station Medical CenterKun Song - College Station Medical CenterLei Tian - Air Force Medical UniversityBin Liu - Air Force Medical UniversityYanpu Liu - Air Force Medical University
- Publication Details
- Bioactive materials, v 7, pp 154-166
- Publisher
- Keai Publishing Ltd
- Number of pages
- 13
- Grant note
- 2020JZ005 / Science and Technology Development Fund; Science and Technology Development Fund (STDF) 2018ZA04 / Research project of National Key Laboratory 2018YFB1107100 / National Key R&D Program of China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000709370300015
- Scopus ID
- 2-s2.0-85107050912
- Other Identifier
- 991021861284704721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials