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Journal article
In vivo compatibility of Dynesys(A (R)) spinal implants: a case series of five retrieved periprosthetic tissue samples and corresponding implants
European spine journal, v 24(5), pp 1074-1084
01 May 2015
PMID: 25480114
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine whether particulate debris is present in periprosthetic tissue from revised Dynesys(A (R)) devices, and if present, elicits a biological tissue reaction.
Five Dynesys(A (R)) dynamic stabilization systems consisting of pedicle screws (Ti alloy), polycarbonate-urethane (PCU) spacers and a polyethylene-terephthalate (PET) cord were explanted for pain and screw loosening after a mean of 2.86 years (1.9-5.3 years). Optical microscopy and scanning electron microscopy were used to evaluate wear, deformation and surface damage, and attenuated total reflectance Fourier transform infrared spectroscopy to assess surface chemical composition of the spacers. Periprosthetic tissue morphology and wear debris were determined using light microscopy, and PCU and PET wear debris by polarized light microscopy.
All implants had surface damage on the PCU spacers consistent with scratches and plastic deformation; 3 of 5 exhibited abrasive wear zones. In addition to fraying of the outer fibers of the PET cords in five implants, one case also evidenced cord fracture. The pedicle screws were unremarkable. Patient periprosthetic tissues around the three implants with visible PCU damage contained wear debris and a corresponding macrophage infiltration. For the patient revised for cord fracture, the tissues also contained large wear particles (> 10 mu m) and giant cells. Tissues from the other two patients showed comparable morphologies consisting of dense fibrous tissue with no inflammation or wear debris.
This is the first study to evaluate wear accumulation and local tissue responses for explanted Dynesys(A (R)) devices. Polymer wear debris and an associated foreign-body macrophage response were observed in three of five cases.
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Details
- Title
- In vivo compatibility of Dynesys(A (R)) spinal implants: a case series of five retrieved periprosthetic tissue samples and corresponding implants
- Creators
- M. Neukamp - University of BernC. Roeder - University of BernS. Y. Veruva - Drexel UniversityD. W. MacDonald - Drexel UniversityS. M. Kurtz - Exponent (United States)M. J. Steinbeck - Drexel University
- Publication Details
- European spine journal, v 24(5), pp 1074-1084
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- R01AR056264 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) NIH R01 AR56264 / NIAMS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000353825700020
- Scopus ID
- 2-s2.0-84939954482
- Other Identifier
- 991019168786204721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Orthopedics