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Accepted (AM)Open Access (License Unspecified), Open
Journal article
In-vivo degradation of poly(carbonate-urethane) based spine implants
Polymer degradation and stability, v 98(6), pp 1225-1235
01 Jun 2013
PMID: 24043907
Abstract
Fourteen explanted Dynesys (R) spinal devices were analyzed for biostability and compared with a reference, never implanted, control. Both poly(carbonate-urethane) (PCU) spacers and polyethyleneterephthalate (PET) cords were analyzed. The effect of implantation was evaluated through the observation of physical alterations of the device surfaces, evaluation of the chemical degradation and fluids absorption on the devices and examination of the morphological and mechanical features. PCU spacers exhibited a variety of surface damage mechanisms, the most significant being abrasion and localized, microscopic surface cracks. Evidence of oxidation and chain scission were detected on PCU spacers by ATR-FTIR. ATR-FTIR, DSC and hardness measurements also showed a slight heterogeneity in the composition of PCU. The extraction carried out on the PCU spacers revealed the presence of extractable polycarbonate segments. One spacer and all PET cords visually exhibited the presence of adherent biological material (proteins), confirmed by the ATR-FTIR results. GC/MS analyses of the extracts from PET cords revealed the presence of biological fluids residues, mainly cholesterol derivatives and fatty acids, probably trapped into the fiber network. No further chemical alterations were observed on the PET cords.
Although the observed physical and chemical damage can be considered superficial, greater attention must be paid to the chemical degradation mechanisms of PCU and to the effect of byproducts on the body. (C) 2013 Elsevier Ltd. All rights reserved.
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Details
- Title
- In-vivo degradation of poly(carbonate-urethane) based spine implants
- Creators
- E. Cipriani - University of TurinP. Bracco - University of TurinS. M. Kurtz - Exponent (United States)L. Costa - University of TurinM. Zanetti - University of Turin
- Publication Details
- Polymer degradation and stability, v 98(6), pp 1225-1235
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- R01AR056264 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) AR56264 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000319546700015
- Scopus ID
- 2-s2.0-84876908194
- Other Identifier
- 991019167471204721
InCites Highlights
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Polymer Science