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Journal article
In vivo neuroprotective effect of a self-assembled peptide hydrogel
Chemical engineering journal (Lausanne, Switzerland : 1996), Vol.408, 127295
15 Mar 2021
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
• Mechanical impact driven injuries of the brain do not heal naturally.
• Self-assembled hydrogels recapitulate features of the extracellular matrix.
• Incorporation of a neuroprotective domain in a self-assembling peptide.
• Injectable hydrogel shown to improve response to traumatic brain injury in vivo.
Traumatic brain injury (TBI) is associated with poor intrinsic healing responses and long-term cognitive decline. A major pathological outcome of TBI is acute glutamate-mediated excitotoxicity (GME) experienced by neurons. Short peptides based on the neuroprotective extracellular glycoprotein ependymin have shown the ability to slow down the effect of GME — however, such short peptides tend to diffuse away from target sites after in vivo delivery. We have designed a self-assembling peptide containing an ependymin mimic that can form nanofibrous matrices. The peptide was evaluated in situ to assess neuroprotective utility after an acute fluid-percussion injury. This biomimetic matrix can conform to the intracranial damaged site after delivery, due its shear-responsive rheological properties. We demonstrated the potential efficacy of the peptide for supporting neuronal survival in vitro and in vivo. Our study demonstrates the potential of these implantable acellular hydrogels for managing the acute (up to 7 days) pathophysiological sequelae after traumatic brain injury. Further work is needed to evaluate less invasive administrative routes and long-term functional and behavioral improvements after injury.
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Details
- Title
- In vivo neuroprotective effect of a self-assembled peptide hydrogel
- Creators
- Biplab Sarkar - New Jersey Institute of TechnologyXiaotang Ma - New Jersey Institute of TechnologyAgnieszka Agas - New Jersey Institute of TechnologyZain Siddiqui - New Jersey Institute of TechnologyPatricia Iglesias-Montoro - New Jersey Institute of TechnologyPeter K. Nguyen - New Jersey Institute of TechnologyKa Kyung Kim - New Jersey Institute of TechnologyJames Haorah - New Jersey Institute of TechnologyVivek A. Kumar - New Jersey Institute of Technology
- Publication Details
- Chemical engineering journal (Lausanne, Switzerland : 1996), Vol.408, 127295
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991021956615704721
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- Domestic collaboration
- Web of Science research areas
- Engineering, Chemical
- Engineering, Environmental