Journal article
In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh
Biomaterials, v 12(2)
1991
PMID: 1652296
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The design of a skin-substitute must address the need for a dermal component, as this mesenchymally-derived tissue is important in maintaining the integrity and function of skin. An
in vivo study was undertaken to assess the use of two biodegradable meshes, polyglycolic acid and polyglactin-910, as carriers for cultured human fibroblasts in a living dermal replacement. The consistent vascularization and epithelialization of these grafts placed on athymic mice showed that this has potential in re-creating the dermis in a skin-substitute.
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Details
- Title
- In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh
- Creators
- Matthew L. Cooper - University of California San Diego Medical CenterJohn F. Hansbrough - University of California San Diego Medical CenterRichard L. Spielvogel - Division of Dermatology, Department of Medicine, Hahnemann University School of Medicine, Philadelphia, PA, USARon Cohen - Marrow-Tech, Incorporated, La Jolla, CA, USARonnda L. Bartel - Marrow-Tech, Incorporated, La Jolla, CA, USAGail Naughton - Marrow-Tech, Incorporated, La Jolla, CA, USARichard J Cohen - Health Management and Policy
- Publication Details
- Biomaterials, v 12(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Management and Policy
- Web of Science ID
- WOS:A1991FE62900024
- Scopus ID
- 2-s2.0-0026092350
- Other Identifier
- 991019183916504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials