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Journal article
In vivo study of the efficacy, biosafety, and degradation of a zinc alloy osteosynthesis system
Acta biomaterialia, v 92, pp 351-361
01 Jul 2019
PMID: 31059834
Abstract
In this study, a comprehensive analysis of a novel zinc alloy osteosynthesis system in a canine mandibular fracture model is presented. The efficacy of the system was compared for PLLA (poly-l-lactic acid) and titanium materials using X-ray radiography, micro-CT tomography, undecalcified bone histomorphometry, and a three-point bending test. Histology, blood normal, blood biochemical, and serum zinc concentration tests were also performed to assess the biosafety of the zinc alloy osteosynthesis system. The degradability of the zinc alloy was evaluated using a micro-CT and scanning electron microscope during the 24-week post operation period. The results showed that zinc alloy possesses good mechanical properties that support fracture healing. Its uniform and slow corrosion leads to adequate degradation behavior in 24 weeks. Additionally, the zinc alloy proved to be biocompatible, indicating that this novel osteosynthesis system is safe for use in the body. The results of the study demonstrate that this zinc alloy-based osteosynthesis system is a promising candidate for a new generation of osteosynthesis systems, with further improvements required in the future.
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Details
- Title
- In vivo study of the efficacy, biosafety, and degradation of a zinc alloy osteosynthesis system
- Creators
- Xiang Wang - State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi’an 710032, PR ChinaXiaoxi Shao - Air Force Medical UniversityTaiqiang Dai - Air Force Medical UniversityFangfang Xu - Air Force Medical UniversityJack G. Zhou - Drexel University, Mechanical Engineering and MechanicsGongqi Qu - BIOLei Tian - Air Force Medical UniversityBin Liu - Air Force Medical UniversityYanpu Liu - Air Force Medical University
- Publication Details
- Acta biomaterialia, v 92, pp 351-361
- Publisher
- Elsevier
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000473380800029
- Scopus ID
- 2-s2.0-85065129496
- Other Identifier
- 991021860702504721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials