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Accepted (AM)Open Access (License Unspecified), Open
Journal article
In vivo trafficking of endogenous opioid receptors
Life sciences (1973), v 83(21), pp 693-699
21 Nov 2008
PMID: 18930741
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Several approaches have been taken for these
in vivo studies. In many studies, the use of semi-quantitative immuno-electron microscopy is the approach of choice. Endogenous opioid receptors display differential subcellular distributions with μ opioid receptor (MOPR) being mostly present on the plasma membrane and δ-opioid receptor (DOPR) and κ-opioid receptor (KOPR) having a significant intracellular pool. Etorphine and DAMGO cause endocytosis of the MOPR, but morphine does not, except in some dendrites. Interestingly, chronic inflammatory pain and morphine treatment promote trafficking of intracellular DOPR to the cell surface which may account for the enhanced antinociceptive effects of DOPR agonists. KOPR has been reported to be associated with secretory vesicles in the posterior pituitary and translocated to the cell surface upon salt loading along with the release of vasopressin. The study of endogenous opioid receptors using
in vivo models has produced some interesting results that could not have been anticipated
in vitro.
In vivo studies, therefore, are essential to provide insight into the mechanisms underlying opioid receptor regulation.
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Details
- Title
- In vivo trafficking of endogenous opioid receptors
- Creators
- Yulin Wang - Temple UniversityElisabeth J. Van Bockstaele - Thomas Jefferson UniversityLee-Yuan Liu-Chen - Temple University
- Publication Details
- Life sciences (1973), v 83(21), pp 693-699
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000261085200001
- Other Identifier
- 991021903301004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy