Logo image
Back
Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS)
Journal article   Open access   Peer reviewed

Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS)

Sandra Urdaneta, Brian Wigdahl, Elizabeth B Neely, Cheston M Berlin, Jr, Cara-Lynne Schengrund, Hung-Mo Lin and Mary K Howett
Retrovirology, v 2(1), pp 28-28
29 Apr 2005
DOI: https://doi.org/10.1186/1742-4690-2-28
PMID: 15888210
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1186/1742-4690-2-28View
Published, Version of Record (VoR) Open

Abstract

Anti-HIV Agents - pharmacology Cell Line HIV-1 - pathogenicity HIV-1 - drug effects HIV Infections - virology Humans Milk, Human - virology T-Lymphocytes - virology Surface-Active Agents - pharmacology Sodium Dodecyl Sulfate - pharmacology Adult Female HIV Infections - transmission HeLa Cells Milk, Human - drug effects Infectious Disease Transmission, Vertical - prevention & control CD4 Antigens - metabolism
Reducing transmission of HIV-1 through breast milk is needed to help decrease the burden of pediatric HIV/AIDS in society. We have previously reported that alkyl sulfates (i.e., sodium dodecyl sulfate, SDS) are microbicidal against HIV-1 at low concentrations, are biodegradable, have little/no toxicity and are inexpensive. Therefore, they may be used for treatment of HIV-1 infected breast milk. In this report, human milk was artificially infected by adding to it HIV-1 (cell-free or cell-associated) and treated with <or=1% SDS (<or=10 mg/ml). Microbicidal treatment was at 37 degrees C or room temperature for 10 min. SDS removal was performed with a commercially available resin. Infectivity of HIV-1 and HIV-1 load in breast milk were determined after treatment. SDS (>or=0.1%) was virucidal against cell-free and cell-associated HIV-1 in breast milk. SDS could be substantially removed from breast milk, without recovery of viral infectivity. Viral load in artificially infected milk was reduced to undetectable levels after treatment with 0.1% SDS. SDS was virucidal against HIV-1 in human milk and could be removed from breast milk if necessary. Milk was not infectious after SDS removal. The proposed treatment concentrations are within reported safe limits for ingestion of SDS by children of 1 g/kg/day. Therefore, use of alkyl sulfate microbicides, such as SDS, to treat HIV1-infected breast milk may be a novel alternative to help prevent/reduce transmission of HIV-1 through breastfeeding.

Metrics

20 Record Views
19 citations in Web of Science
22 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being
#5 Gender Equality

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Virology
Logo image