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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Inactivation of astroglial NF-κB promotes survival of retinal neurons following ischemic injury
The European journal of neuroscience, v 30(2)
01 Jul 2009
PMID: 19614983
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Reactive astrocytes have been implicated in neuronal loss following ischemic stroke. However, the molecular mechanisms associated with this process are yet to be fully elucidated. In this work, we tested the hypothesis that astroglial NF-κB, a key regulator of inflammatory responses, is a contributor to neuronal death following ischemic injury. We compared neuronal survival in the ganglion cell layer after retinal ischemia-reperfusion in wild type and in GFAP-IκBα-dn transgenic mice, where the NF-κB classical pathway is suppressed specifically in astrocytes. The GFAP-IκBα-dn mice showed significantly increased survival of neurons in the ganglion cell layer following ischemic injury as compared to WT littermates. Neuroprotection was associated with significantly reduced expression of pro-inflammatory genes, encoding
Tnf-α, Ccl2 (Mcp1), Cxcl10 (IP10), Icam1, Vcam1
, several subunits of NADPH oxidase and NO synthase in the retinas of GFAP-IκBα-dn mice. These data suggest that certain NF-κB-regulated pro-inflammatory and redox-active pathways are central to glial neurotoxicity induced by ischemic injury. The inhibition of these pathways in astrocytes may represent a feasible neuroprotective strategy for retinal ischemia and stroke.
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Details
- Title
- Inactivation of astroglial NF-κB promotes survival of retinal neurons following ischemic injury
- Creators
- Galina Dvoriantchikova - University of MiamiDavid Barakat - University of MiamiRoberta Brambilla - University of MiamiChristian Agudelo - University of MiamiEleut Hernandez - University of MiamiJohn R. Bethea - University of MiamiValery I. Shestopalov - University of MiamiDmitry Ivanov - University of Miami
- Publication Details
- The European journal of neuroscience, v 30(2)
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000268169200002
- Scopus ID
- 2-s2.0-67651148406
- Other Identifier
- 991020100196104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences