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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Inactivation of the thalamic paraventricular nucleus promotes place preference and sucrose seeking in male rats
Psychopharmacology, v 239(8), pp 2659-2671
01 Aug 2022
PMID: 35524009
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rationale The experience of reward entails both positive affect and motivation. While the brain regions responsible for these distinct aspects of reward are dissociable from each other, the paraventricular nucleus of the thalamus (PVT) may play a role in both. Objectives To investigate the role of the PVT in both affect and motivation, and to identify neuropeptides that might mediate these effects. Methods Male rats were tested for conditioned place preference following temporary inactivation of the anterior or posterior PVT with local injections of the GABA(B) and GABA(A) agonists, baclofen + muscimol. They were tested for sucrose seeking under a fixed ratio 3 (FR3) schedule of reinforcement and after extinction, following injection into the posterior PVT of baclofen + muscimol or saline vehicle. Finally, quantitative real-time PCR was used to examine local neuropeptide gene expression following injection into the posterior PVT of baclofen + muscimol or saline vehicle. Results Conditioned place preference was induced by temporary inactivation of the posterior but not anterior PVT. While sucrose seeking under an FR3 schedule of reinforcement was unaffected by inactivation of the posterior PVT, reinstatement of sucrose seeking was promoted by posterior PVT inactivation. Local gene expression of pituitary adenylate cyclase-activating polypeptide (PACAP), but not enkephalin or neurotensin, was reduced following inactivation of the posterior PVT. Conclusions Temporary inactivation of the posterior PVT affects both affect and motivation as well as local gene expression of PACAP. These results suggest that the posterior PVT is one brain region that may participate in both major aspects of reward.
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Details
- Title
- Inactivation of the thalamic paraventricular nucleus promotes place preference and sucrose seeking in male rats
- Creators
- Andrew T. Gargiulo - Drexel UniversityPreeti S. Badve - Drexel Univ, Dept Neurobiol & Anat, Coll Med, 2900 Queen Lane, Philadelphia, PA 19129 USAGenevieve R. Curtis - Drexel Univ, Dept Neurobiol & Anat, Coll Med, 2900 Queen Lane, Philadelphia, PA 19129 USABreanne E. Prino - Drexel Univ, Dept Neurobiol & Anat, Coll Med, 2900 Queen Lane, Philadelphia, PA 19129 USAJessica R. Barson - Drexel University
- Publication Details
- Psychopharmacology, v 239(8), pp 2659-2671
- Publisher
- Springer Nature
- Number of pages
- 13
- Grant note
- R01AA028218 / National Institute on Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000791671800001
- Scopus ID
- 2-s2.0-85129505155
- Other Identifier
- 991021900514604721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry