Journal article
Incidence of lymphoma associated with underlying lupus: lessons learned from observational studies
Current opinion in rheumatology, v 26(2), pp 111-117
01 Mar 2014
PMID: 24419748
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose of reviewThe increased risk of overall malignancy in systemic lupus erythematosus (SLE) is well established. Cohort studies have shown a significant association of non-Hodgkin's lymphoma with SLE. This review will focus on the associated risk factors, the role of immunology, immunosuppressive medications and secondary Sjogren's syndrome in the development of lymphoma in SLE.Recent findingsCohort studies have established the link between non-Hodgkin's lymphoma and SLE. The largest study to date has been of 16409 patients from 30 rheumatologic centres. In the last decade, insights into the roles of BAFF (BLyS) and APRIL in lymphoma development have helped to understand the mechanism leading to monoclonality. Genetic markers have helped to prognosticate diffuse large B-cell lymphoma. The contribution of disease activity and immunosuppressive drugs in lymphoma development is still not understood in SLE.SummaryAlthough the association of non-Hodgkin's lymphoma in SLE is well established, risk factors attributing to this association are still not understood.
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Details
- Title
- Incidence of lymphoma associated with underlying lupus: lessons learned from observational studies
- Creators
- Tanmayee Bichile - Johns Hopkins MedicineMichelle Petri - Johns Hopkins Medicine
- Publication Details
- Current opinion in rheumatology, v 26(2), pp 111-117
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000332829900006
- Scopus ID
- 2-s2.0-84894032595
- Other Identifier
- 991022193497604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Rheumatology