Journal article
Incidence, outcomes, and predictors of in-hospital acute coronary syndrome following endovascular transcatheter aortic valve replacement in the United States
Catheterization and cardiovascular interventions, v 96(5), pp E527-E534
01 Nov 2020
PMID: 31868320
Abstract
Background Incidence and outcomes of acute coronary syndrome (ACS) immediately following transcatheter aortic valve replacement (TAVR) remain largely unknown. Objectives This study sought to assess the incidence, clinical characteristics, and outcomes of ACS following TAVR. Methods We queried the National Readmission Database from January 2012 to September 2015 for TAVR admissions with and without ACS, creating a propensity-matched cohort to compare outcomes. Results A total of 48,454 patients underwent TAVR, with 1,332 (2.75%) developing ACS. TAVR patients with ACS compared to those without ACS had a significantly higher incidence of acute kidney injury (24.7 vs. 19.2%; p = .001), ischemic stroke (3.7 vs. 2.3%; p = .04), vascular complications (8.6 vs. 5.8%; p = .008), cardiogenic shock (9.8 vs. 1.9%; p < .001), cardiac arrest (5.1 vs. 2.8%; p = .002), mechanical circulatory support (8.1 vs. 1.5%; p < .001), and in-hospital mortality (9.6 vs. 3.4%; p < .001). Additionally, TAVR with ACS had longer lengths of stay (median 10 days vs. 6 days; p < .001) and hospital charges (median $23,200 vs. $19,000; p < .001). Positive predictors of ACS were history of PCI (odds ratio, 1.43; 95% CI: 1.25-1.63), hyperlipidemia (odds ratio, 1.20; 95% CI: 1.07-1.34), chronic blood loss anemia (odds ratio, 2.16; 95% CI: 1.54-3.03), chronic kidney disease (odds ratio, 1.17; 95% CI: 1.04-1.31), fluid and electrolyte disorders (odds ratio, 1.65; 95% CI: 1.47-1.85), and weight loss (odds ratio, 1.53; 95% CI: 1.22-1.91). Heart failure (34%) was the most common reason for readmission in the ACS cohort. Conclusion ACS after TAVR is uncommon but is associated with worse clinical outcomes and increased healthcare resource utilization.
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Details
- Title
- Incidence, outcomes, and predictors of in-hospital acute coronary syndrome following endovascular transcatheter aortic valve replacement in the United States
- Creators
- Salik Nazir - University of Toledo Medical CenterKeerat R. Ahuja - Cleveland ClinicAnthony Donato - Reading HospitalRobert D. Grande - ProMedica Toledo HospitalKhalid Changal - University of Toledo Medical CenterMohamed M. Gad - Cleveland ClinicAnas Saad - Cleveland ClinicBeni R. Verma - Cleveland ClinicMubasshar A. Syed - University of ToledoMujeeb Sheikh - University of Toledo Medical CenterSamir Kapadia - Cleveland ClinicP. Kasi Ramanathan - ProMedica Toledo Hospital
- Publication Details
- Catheterization and cardiovascular interventions, v 96(5), pp E527-E534
- Publisher
- Wiley
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000503876700001
- Scopus ID
- 2-s2.0-85077161706
- Other Identifier
- 991022161733804721