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Journal article
Inclusion of Biological Targets in the Analysis of Electrical Characteristics of Non-Thermal Plasma Discharge
Plasma, v 6(3), pp 577-591
01 Sep 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In Plasma Medicine studies, the effect of non-thermal plasma (NTP) on biological targets is typically correlated with the amount of stable reactive oxygen and nitrogen species produced in a liquid medium. The effect of NTP and the response of the biological target on cellular redox mechanisms is overlooked in these investigations. Additionally, the influence of electrical properties of cells on the physical properties of NTP is neglected. Therefore, we used a floating electrode dielectric barrier discharge plasma to explore the impact of cell structure, size, and viability of the biological target on the physical properties of NTP. Lissajous figures were used to determine circuit capacitance and energy per cycle during NTP exposure of different cell suspensions. We show that both, structural integrity and active enzymic processes of cells change the electrical properties of NTP. Correlations were also drawn between NTP-produced hydrogen peroxide and nitrite with measured capacitance. Our studies indicate that the observed changes between different cell suspensions may be due to a feedback loop between the biological target and the NTP source. In future studies, a more detailed analysis is needed to improve the control of clinical NTP devices.
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Details
- Title
- Inclusion of Biological Targets in the Analysis of Electrical Characteristics of Non-Thermal Plasma Discharge
- Creators
- Julia Sutter - Drexel UniversityJascha Brettschneider - Drexel UniversitySara Mamchur - Drexel UniversityFred Krebs - Drexel UniversitySophia Gershman - Princeton Plasma Physics LaboratoryVandana Miller - Drexel University
- Publication Details
- Plasma, v 6(3), pp 577-591
- Publisher
- Mdpi
- Number of pages
- 15
- Grant note
- Princeton Collaborative Research Facility (PCRF) Department of Microbiology and Immunology DE-AC02-09CH11466 / U.S. Department of Energy (DOE); United States Department of Energy (DOE) Institute for Molecular Medicine and Infectious Disease at the Drexel University College of Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Microbiology Department Internal Research
- Web of Science ID
- WOS:001074392400001
- Scopus ID
- 2-s2.0-85172882280
- Other Identifier
- 991021463535604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physics, Fluids & Plasmas