Journal article
Incorporating O sub(2)-Hb reaction kinetics and the Fahraeus effect into a microcirculatory O sub(2)CO sub(2) transport model
IEEE transactions on biomedical engineering, Vol.45(1)
01 Jan 1998
Abstract
The influence of O sub(2)-Hb reaction kinetics and the Fahraeus effect on steady state O sub(2) and CO sub(2) transport in cat brain microcirculation was investigated using our refined multicompartmental model. The most important model predictions include: 1) capillaries are the sites in the microcirculation where the effect of O sub(2)-Hb kinetics is most pronounced; 2) while there is only a small difference between equilibrium and actual oxygen saturation, this effect is not negligible; 3) O sub(2)-Hb kinetics tends to make the PO sub(2) level at the venous entrance higher than in venules; 4) the influence of the Fahraeus effect leads to a lower tissue PO sub(2) level than in venules and the outlet vein. The resultant decline in tissue PO sub(2) may lead to a decrease in O sub(2) consumption rate and extraction ratio; 5) although the Fahraeus effect changes the ratio between arteriolar flux and capillary flux, incorporating the Fahraeus effect and O sub(2)-Hb kinetics into the simulation does not change our previous conclusion that most of the O sub(2) and CO sub(2) exchange takes place at the capillary level; 6) in general, influences of O sub(2)-Hb kinetics and Fahraeus effect are synergistic; 7) a model that excludes these two mechanisms might overestimate the tissue oxygenation level especially during severe hypoxia.
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Details
- Title
- Incorporating O sub(2)-Hb reaction kinetics and the Fahraeus effect into a microcirculatory O sub(2)CO sub(2) transport model
- Creators
- Guo-Fan YeJin ParkRaghuveer BasudeDonald BuerkDov Jaron
- Publication Details
- IEEE transactions on biomedical engineering, Vol.45(1)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]; Drexel University
- Identifiers
- 991019341962804721