Journal article
Incorporating O2-Hb reaction kinetics and the Fåhraeus effect into a microcirculatory O2-CO2 transport model
IEEE transactions on biomedical engineering, v 45(1)
Jan 1998
PMID: 9444837
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The influence of O2-Hb reaction kinetics and the Fåhraeus effect on steady state O2 and CO2 transport in cat brain microcirculation was investigated using our refined multicompartmental model. The most important model predictions include: 1) capillaries are the sites in the microcirculation where the effect of O2-Hb kinetics is most pronounced; 2) while there is only a small difference between equilibrium and actual oxygen saturation, this effect is not negligible; 3) O2-Hb kinetics tends to make the PO2 level at the venous entrance higher than in venules; 4) the influence of the Fåhraeus effect leads to a lower tissue PO2 level than in venules and the outlet vein. The resultant decline in tissue PO2 may lead to a decrease in O2 consumption rate and extraction ratio; 5) although the Fåhraeus effect changes the ratio between arteriolar flux and capillary flux, incorporating the Fåhraeus effect and O2-Hb kinetics into the simulation does not change our previous conclusion, that most of the O2 and CO2 exchange takes place at the capillary level; 6) in general, influences of O2-Hb kinetics and Fåhraeus effect are synergistic; 7) a model that excludes these two mechanisms might overestimate the tissue oxygenation level especially during severe hypoxia.
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Details
- Title
- Incorporating O2-Hb reaction kinetics and the Fåhraeus effect into a microcirculatory O2-CO2 transport model
- Creators
- G F Ye - New Concept Development Division, Redwood City, CA 94063, USA. yegf@hotmail.comJ W ParkR BasudeD G BuerkD Jaron
- Publication Details
- IEEE transactions on biomedical engineering, v 45(1)
- Publisher
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE); United States
- Grant note
- EY09269 / NEI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:000071030900004
- Scopus ID
- 2-s2.0-0031594122
- Other Identifier
- 991014877870404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical