Journal article
Increase in CD4 Lymphocyte Counts After Splenectomy in HIV-infected Patients
The American journal of the medical sciences, v 306(2), pp 105-110
Aug 1993
PMID: 8103284
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The records were reviewed of five human immunodeficiency virus (HIV) type 1-infected patients who underwent splenectomy, four for HIV-associated thrombocytopenia and one for gastric compression secondary to splenomegaly. After splenectomy, the four adult patients all had marked, sustained increases in their absolute CD4 lymphocyte counts; greater increases were observed in CD8 lymphocyte counts, accounting for decreases in the CD4:CD8 ratios. In patient 5 (one of triplets, all of whom were infected with HIV after a blood transfusion), absolute CD4 lymphocyte counts were stabilized after splenectomy; the other siblings manifested a decline in CD4 counts, which was associated with a delay in physical development and recurrent episodes of varicella. Immunohistochemical staining of spleen sections demonstrated significantly higher numbers of CD4 cells in splenic tissue from HIV-infected patients than from patients splenectomized secondary to trauma (2, 070±284 vs. 962±296; p=0.025). In addition, the HIV-infected patients had significantly higher percentages of CD4 lymphocytes in splenic tissue than in peripheral blood (49.3±11.0 vs. 20.3±7.9; p=0.005), suggesting that CD4 cells were sequestered in the spleens of these patients. These findings have implications for the management of splenectomized HIV-infected patients with regard to optimal timing of initiation of zidovudine therapy and for prophylaxis of Pneumocystis carinii pneumonia.
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Details
- Title
- Increase in CD4 Lymphocyte Counts After Splenectomy in HIV-infected Patients
- Creators
- Allan R. Tunkel - Drexel UniversityBrian Kelsall - University of VirginiaMichael F. Rein - University of VirginiaDonald J. Innes - University of VirginiaFrank T. Saulsbury - University of VirginiaKelly Vollmer - University of VirginiaBrian Wispelwey - University of Virginia
- Publication Details
- The American journal of the medical sciences, v 306(2), pp 105-110
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Web of Science ID
- WOS:A1993LQ78700009
- Scopus ID
- 2-s2.0-0027290023
- Other Identifier
- 991019346721304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, General & Internal