Journal article
Increased Age, but Not Parity Predisposes to Higher Bacteriuria Burdens Due to Streptococcus Urinary Tract Infection and Influences Bladder Cytokine Responses, Which Develop Independent of Tissue Bacterial Loads
PloS one, v 11(12), pp e0167732-e0167732
09 Dec 2016
PMID: 27936166
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Streptococcus agalactiae causes urinary tract infection (UTI) in pregnant adults, non-pregnant adults, immune-compromised individuals and the elderly. The pathogenesis of S. agalactiae UTI in distinct patient populations is poorly understood. In this study, we used murine models of UTI incorporating young mice, aged and dam mice to show that uropathogenic S. agalactiae causes bacteriuria at significantly higher levels in aged mice compared to young mice and this occurs coincident with equivalent levels of bladder tissue colonisation at 24 h post-infection (p.i.). In addition, aged mice exhibited significantly higher bacteriuria burdens at 48 h compared to young mice, confirming a divergent pattern of bacterial colonization in the urinary tract of aged and young mice. Multiparous mice, in contrast, exhibited significantly lower urinary titres of S. agalactiae compared to age-matched nulliparous mice suggesting that parity enhances the ability of the host to control S. agalactiae bacteriuria. Additionally, we show that both age and parity alter the expression levels of several key regulatory and pro-inflammatory cytokines, which are known to be important the immune response to UTI, including Interleukin (IL)-1 beta, IL-12(p40), and Monocyte Chemoattractant Protein-1 (MCP-1). Finally, we demonstrate that other cytokines, including IL-17 are induced significantly in the S. agalactiae-infected bladder regardless of age and parity status. Collectively, these findings show that the host environment plays an important role in influencing the severity of S. agalactiae UTI; infection dynamics, particularly in the context of bacteriuria, depend on age and parity, which also affect the nature of innate immune responses to infection.
Metrics
Details
- Title
- Increased Age, but Not Parity Predisposes to Higher Bacteriuria Burdens Due to Streptococcus Urinary Tract Infection and Influences Bladder Cytokine Responses, Which Develop Independent of Tissue Bacterial Loads
- Creators
- Matthew J. Sullivan - Griffith UniversityAlison J. Carey - Griffith UniversitySophie Y. Leclercq - Griffith UniversityChee K. Tan - Griffith UniversityGlen C. Ulett - Griffith University
- Publication Details
- PloS one, v 11(12), pp e0167732-e0167732
- Publisher
- Public Library Science
- Number of pages
- 16
- Grant note
- Griffith Health Institute APP1052464 / NHMRC; National Health and Medical Research Council (NHMRC) of Australia APP1005315 / National Health and Medical Research Council (NHMRC); National Health and Medical Research Council (NHMRC) of Australia 248427/2013-0 / Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)-Brazil; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) FT110101048 / Australian Research Council
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Drexel University
- Web of Science ID
- WOS:000389587100167
- Scopus ID
- 2-s2.0-85005950237
- Other Identifier
- 991020099991004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology