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Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8 + T Cells
Journal article   Open access   Peer reviewed

Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8 + T Cells

Yvonne M Mueller, Stephen C De Rosa, Justin A Hutton, James Witek, Mario Roederer, John D Altman and Peter D Katsikis
Immunity (Cambridge, Mass.), v 15(6), pp 871-882
2001
DOI: https://doi.org/10.1016/S1074-7613(01)00246-1
PMID: 11754810
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://www.cell.com/article/S1074761301002461/pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1016/S1074-7613(01)00246-1View
Published, Version of Record (VoR) Open

Abstract

Why HIV-specific CD8 + T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8 + T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8 + T cells from the same patients. HIV-specific CD8 + T cells express the CD45RA −CD62L − but lack the CD45RA +CD62L − T cell effector memory (T EM) phenotype. This skewing is not found in CMV- and EBV-specific CD8 + T cells in HIV-infected individuals. CD95/Fas-induced apoptosis is much higher in the CD45RA −CD62L − T EM cells. However, cytotoxicity and IFNγ production by HIV-specific CD8 + T cells is not impaired. Our data suggest that the survival and differentiation of HIV-specific CD8 + T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.

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138 citations in Web of Science
149 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Immunology
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