Journal article
Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection
The Journal of immunology (1950), v 182(3), pp 1439-1448
01 Feb 2009
PMID: 19155491
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Acute SIV infection is characterized by explosive infection of memory CD4 T cells in peripheral and mucosal tissues. Interestingly, relatively few memory CD4 T cells are infected until as late as days 7-8 after challenge. However, by day 10 postinfection, most of the memory CD4 T cells are infected and carry viral DNA. The rapidity with which infection expands within 2-3 days to encompass virtually the entire memory CD4 T cell compartment suggests significant alterations in the susceptibility of memory CD4 T cells to infection during this period. The mechanism(s) underlying this increased permissiveness to infection is not known. In this study, we show that IL-15 secretion significantly correlates with the up-regulated expression of CD4 on memory CD4 T cells that is associated with increased permissiveness to SIV infection. Activation and proliferation of memory CD8, but not memory CD4 T cells, preceded the amplification of viral infection. Although memory CD4 T cells did not express normal activation markers, they displayed a significant up-regulation in the density of CD4 but not CCR5 expression between days 7 and 10 postinfection that correlated with increased plasma IL-15 levels and infection in these cells. Culture of purified CD4 T cells with IL-15 and/or SIV was associated with a significant increase in the expression of CD4 and infection of these sorted cells. Our results demonstrate that IL-15 contributes to the increased susceptibility of memory CD4 T cells to SIV during the early phase of acute SIV infection.
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Details
- Title
- Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection
- Creators
- Matthew D Eberly - Uniformed Services University of the Health SciencesMuhamuda Kader - Uniformed Services University of the Health SciencesWail Hassan - Uniformed Services University of the Health SciencesKenneth A Rogers - Emory UniversityJianzhong Zhou - Emory UniversityYvonne M Mueller - Drexel UniversityMary J Mattapallil - National Eye InstituteMichael Piatak, JrJeffrey D Lifson - Science Applications International Corporation (United States)Peter D Katsikis - Drexel UniversityMario Roederer - Vaccine Research CenterFrancois Villinger - Emory UniversityJoseph J Mattapallil - Uniformed Services University of the Health Sciences
- Publication Details
- The Journal of immunology (1950), v 182(3), pp 1439-1448
- Publisher
- American Association of Immunologists (AAI)
- Grant note
- R21 DE018339-02 / NIDCR NIH HHS R21 DE018339-02S1 / NIDCR NIH HHS R01 AI062437 / NIAID NIH HHS R01 DE019397 / NIDCR NIH HHS N01-CO-124000 / NCI NIH HHS K22 AI07812 / NIAID NIH HHS K22 AI071812 / NIAID NIH HHS K22 AI071812-01 / NIAID NIH HHS R21 DE018339-01 / NIDCR NIH HHS R21 DE018339 / NIDCR NIH HHS K22 AI071812-02 / NIAID NIH HHS R01 AI062437-04 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000262842100028
- Scopus ID
- 2-s2.0-63149109249
- Other Identifier
- 991019339564704721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology