Journal article
Increased Risk of Herpes Zoster in Adult Patients with Inflammatory Bowel Disease After SARS-CoV2 Infection: A Propensity-Matched Cohort Study
Inflammatory bowel diseases, v 30(7), pp 1094-1102
03 Jul 2024
PMID: 37540900
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There is evidence that SARS-CoV2 infection can increase the risk of herpes zoster (HZ) in the general population. However, the risk in patients with inflammatory bowel disease (IBD) is not known.
The TriNetX database was utilized to conduct a retrospective cohort study in patients with IBD after SARS-CoV2 infection and patients without a SARS-CoV2 infection (IBD control cohort). The primary outcome was to evaluate the risk of HZ between the 2 cohorts. One-to-one (1:1) propensity score matching was performed for demographic parameters, HZ risk factors and IBD medications between the 2 cohorts. Adjusted odds ratio (aOR) with 95% confidence interval (CI) were calculated.
After propensity score matching, patients with IBD with a SARS-CoV2 infection were at an increased risk for HZ (aOR, 2.16; 95% CI, 1.53-3.04) compared with IBD control cohort in the pre-COVID-19 vaccine era. There was no difference in the risk (aOR, 0.87; 95% CI, 0.44-1.75) of a composite outcome of HZ complications (hospitalization, post-herpetic neuralgia, and neurologic complications) between the 2 cohorts. The IBD SARS-CoV2 cohort was also at an increased risk for HZ (aOR, 3.04; 95% CI, 1.48-6.24) compared with IBD control cohort in the postvaccine era. However, the risk of HZ in the postvaccine era was decreased (aOR, 0.45; 95% CI, 0.27-0.76) compared with IBD SARS-CoV2 cohort in the prevaccine era.
Our study showed that SARS-CoV2 infection is associated with an increased risk of HZ in patients with IBD.
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Details
- Title
- Increased Risk of Herpes Zoster in Adult Patients with Inflammatory Bowel Disease After SARS-CoV2 Infection: A Propensity-Matched Cohort Study
- Creators
- Aakash Desai - Case Western Reserve UniversityAakriti Soni - Saint Vincent HospitalMary S Hayney - University of Wisconsin–MadisonJana G Hashash - Mayo Clinic in FloridaGursimran S Kochhar - Allegheny Health NetworkFrancis A Farraye - Mayo Clinic in FloridaFreddy Caldera - University of Wisconsin–Madison
- Publication Details
- Inflammatory bowel diseases, v 30(7), pp 1094-1102
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001042346300001
- Scopus ID
- 2-s2.0-85197594882
- Other Identifier
- 991022135681304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology