Journal article
Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cells
Blood, v 109(6), pp 2505-2513
15 Mar 2007
PMID: 17095625
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
What governs the increased apoptosis sensitivity of HIV-specific CD8
+
T cells is poorly understood. Here, we examined the involvement of mitochondria in this apoptosis. Remarkably higher mitochondrial mass (MM) was found in HIV-specific compared with CMV-specific CD8
+
T cells from HIV
+
patients and this could not be attributed to their different differentiation status. MM
High
phenotype characterized those CD8
+
T cells from HIV
+
patients that are sensitive to spontaneous and CD95/Fas-induced apoptosis. CD38 expression did not correlate with high MM, whereas Bcl-2 levels were significantly reduced in both CD38
+
and CD38
−
HIV-specific CD8
+
T cells. Although CD38
+
HIV-specific CD8
+
T cells were more susceptible to apoptosis, CD38 expression does not explain on its own the selective apoptosis sensitivity of HIV-specific CD8
+
T cells, as CD38
−
HIV-specific CD8
+
T cells were more apoptotic than CD38
+
CMV-specific ones. Proapoptotic HIV-specific CD8
+
T cells were CD38
+
Bcl-2
Low
MM
High
. Copolarization of mitochondria with CD95/Fas capping, very early in CD95/Fas-induced apoptosis of HIV-specific CD8
+
T cells, suggests that mitochondria act as an amplification step for this apoptosis. Thus, an extensive mitochondrial network contributes to apoptosis sensitivity of CD8
+
T cells and, when this occurs together with reduced levels of Bcl-2 and chronic activation, determines the proapoptotic state of HIV-specific CD8
+
T cells.
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Details
- Title
- Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cells
- Creators
- Constantinos Petrovas - Drexel UniversityYvonne M. Mueller - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Disease andIoannis D. Dimitriou - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Disease andSusan R. Altork - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Disease andAnupam Banerjee - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Disease andPeter Sklar - Drexel UniversityKaram C. Mounzer - Philadelphia FightJohn D. Altman - Emory UniversityPeter D. Katsikis - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Disease and
- Publication Details
- Blood, v 109(6), pp 2505-2513
- Series
- Immunobiology
- Publisher
- American Society of Hematology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000245004700039
- Scopus ID
- 2-s2.0-33947191128
- Other Identifier
- 991019167883604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology