Journal article
Increased neuronal nuclear calcium influx in neonatal seizures
Neurochemical research, v 31(10), pp 1231-1237
01 Oct 2006
PMID: 17004131
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We hypothesized that neonatal seizures lead to increased Ca(2+) influx (nCa(2+)I) in neuronal nuclei of newborn rats and that such increase is nitric-oxide mediated. Neuronal nuclear (45)Ca(2+) influx (nCa(2+)I) was measured in neuronal nuclei of 25 10-day-old male rat-pups newborn brains. They were divided into five groups (n = 5/group). (I) control; (II) hypoxia without seizures; (III) hypoxia with seizures; (IV) kainate, 2 mg/kg intraperitoneal (i.p.)-induced seizures and (V) 7-nitroindazole (7-NINA), 1 mg/kg i.p. pretreated, kainate-induced seizures. nCa(2+)I was significantly (P < 0.05) increased following hypoxia or seizures (hypoxic- or kainate-induced). Post-hypoxic seizures further enhanced nCa(2+)I increase induced by hypoxia (P < 0.05). 7-NINA abated the nCa(2+)I increase induced by kainate. We conclude that (1) kainate or hypoxia-induced seizures in newborn rats modify the neuronal nuclear membrane function, resulting in increased nCa(2+)I, (2) seizures exacerbate the hypoxia-induced increased nCa(2+)I incurred after hypoxia and (3) intranuclear calcium surges during kainate-induced neonatal seizures are nitric oxide-mediated.
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Details
- Title
- Increased neuronal nuclear calcium influx in neonatal seizures
- Creators
- Ignacio Valencia - Drexel UniversityOm P Mishra - St. Christopher's Hospital for ChildrenKaren Fritz - St. Christopher's Hospital for ChildrenAlan Zubrow - St. Christopher's Hospital for ChildrenChristos D Katsetos - Drexel UniversityMaria Delivoria-Papadopoulos - St. Christopher's Hospital for ChildrenAgustín Legido - Drexel University
- Publication Details
- Neurochemical research, v 31(10), pp 1231-1237
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000241792900008
- Scopus ID
- 2-s2.0-33750712406
- Other Identifier
- 991019168667304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences