Journal article
Increased resting-state global functional connectivity density of default mode network in schizophrenia subjects treated with electroconvulsive therapy
Schizophrenia research, v 197, pp 192-199
Jul 2018
PMID: 29117910
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Abstract
Modified electroconvulsive therapy (MECT) has been widely applied to help treat schizophrenia patients who are treatment-resistant to pharmaceutical therapy. Although the technique is increasingly prevalent, the underlying neural mechanisms have not been well clarified. We conducted a longitudinal study to investigate the alteration of global functional connectivity density (gFCD) in schizophrenia patients undergoing MECT using resting state fMRI (functional magnetic resonance imaging). Two groups of schizophrenia inpatients were recruited. One group received a four-week MECT together with antipsychotic drugs (ECT+Drug, n=21); the other group only received antipsychotic drugs (Drug, n=21). Both groups were compared to a sample of healthy controls (HC, n=23). fMRI scans were obtained from the schizophrenia patients twice at baseline (t1) and after 4-week treatment (t2), and from healthy controls at baseline. gFCD was computed using resting state fMRI. Repeated ANCOVA showed a significant interaction effect of group×time in the schizophrenia patients in left precuneus (Pcu), ventral medial prefrontal cortex (vMPFC), and dorsal medial prefrontal cortex (dMPFC) (GRF-corrected P<0.05), which are mainly located within the default mode network (DMN). Post-hoc analysis revealed that compared with baseline (t1), an increased gFCD was found in the ECT+Drug group in the dMPFC (t=3.87, p=0.00095), vMPFC (t=3.95, p=0.00079) and left Pcu (t=3.33, p=0.0034), but no significant effect was identified in the Drug group. The results suggested that increased global functional connectivity density within the DMN might be one important neural mechanism of MECT in schizophrenia.
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Details
- Title
- Increased resting-state global functional connectivity density of default mode network in schizophrenia subjects treated with electroconvulsive therapy
- Creators
- Huan Huang - Shanghai Mental Health CenterYuchao Jiang - University of Electronic Science and Technology of ChinaMengqing Xia - Shanghai Mental Health CenterYingying Tang - Shanghai Mental Health CenterTianhong Zhang - Shanghai Mental Health CenterHuiru Cui - Shanghai Mental Health CenterJunjie Wang - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, ChinaYu Li - Shanghai Mental Health CenterLihua Xu - Shanghai Mental Health CenterAdrian Curtin - Shanghai Jiao Tong UniversityJianhua Sheng - Shanghai Mental Health CenterYuping Jia - Shanghai Mental Health CenterDezhong Yao - University of Electronic Science and Technology of ChinaChunbo Li - Shanghai Jiao Tong UniversityCheng Luo - University of Electronic Science and Technology of ChinaJijun Wang - Shanghai Mental Health Center
- Publication Details
- Schizophrenia research, v 197, pp 192-199
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000437786100030
- Scopus ID
- 2-s2.0-85033225786
- Other Identifier
- 991019168357904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry