Journal article
Increased serum concentration of the soluble interleukin-2 receptor in cutaneous T-cell lymphoma - Clinical and prognostic implications
Archives of dermatology (1960), v 132(1), pp 42-47
01 Jan 1996
PMID: 8546482
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Design: The serum concentration of soluble alpha-chain receptor for interleukin-2 (sIL-2R) was determined in 101 patients with cutaneous T-cell lymphoma (CTCL).
Results: The serum concentration of sIL-2R correlates positively with CTCL tumor burden as determined by several clinical parameters tie, clinical subtype of disease, extent of skin involvement, T rating, and stage), by serum lactate dehydrogenase concentration, and by Sezary cell counts in erythrodermic disease. The median value of sIL-2R in erythrodermic CTCL was more than threefold higher than that of classic mycosis fungoides (MF). The proportion of patients with elevated sIL-2R concentration (>1000 U/mL) also increased in CTCL in a similar fashion according to the clinical type of disease (MF patch phase, 15%; MF plaque phase, 33%; MF tumor phase, 47%; and erythrodermic variants, 90%). However, no correlation was found between sIL-2R serum concentration and expression of membrane-bound IL-2R alpha chain (CD25) on lymphoid cells in skin lesions and peripheral blood. Significantly, multivariate analysis of various prognostic factors demonstrated that in erythrodermic CTCL, sIL-2R serum concentration correlated best with survival and was a better predictor of prognosis than stage, Sezary cell counts, or lactate dehydrogenase values.
Conclusions: These findings document the usefulness of the measurement of the sIL-2R serum concentration to determine tumor burden and prognosis in patients with CTCL.
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Details
- Title
- Increased serum concentration of the soluble interleukin-2 receptor in cutaneous T-cell lymphoma - Clinical and prognostic implications
- Creators
- M A WasikE C VonderheidR D BiglerR MartiLessinM PolanskyM E Kadin
- Publication Details
- Archives of dermatology (1960), v 132(1), pp 42-47
- Publisher
- Amer Medical Assoc
- Number of pages
- 6
- Grant note
- R29CA055017 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) AR40404 / NIAMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) R01AR040404 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) CA54062; CA55017 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1996TP70200006
- Scopus ID
- 2-s2.0-0030021384
- Other Identifier
- 991019168961304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Dermatology