Journal article
Increased stiffness of extracellular matrix enhanced chemoresistance in 3D-bioprinted ovarian cancer model
International journal of bioprinting, p1673
18 Jan 2024
Abstract
Ovarian cancer is a gynecological malignancy with a high mortality rate. The ovarian cancer microenvironment is a crucial factor affecting the overall and progression-free survival rates of patients with ovarian cancer. The biophysical factors of the tumor microenvironment, such as stiffness, can affect the gene expression and behavior of tumor cells. In this study, we utilized 3D bioprinting technology to construct ovarian cancer tumor models with varying levels of stiffness in vitro to investigate the effect of extracellular matrix stiffness on drug resistance of tumor cells. Our findings indicate that increasing the stiffness of extracellular matrix can attenuate the sensitivity of tumor cells to chemotherapeutic agents. Additionally, the increased stiffness of 3D tumor model may promote malignant phenotypes, such as tumor stemness and tumor progression.
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Details
- Title
- Increased stiffness of extracellular matrix enhanced chemoresistance in 3D-bioprinted ovarian cancer model
- Creators
- Ying ShanMingchang PangLiqian WangYixin MaoRuiyi YanChang ZhouJingyuan JiYilei MaoYing JinHuayu Yang
- Publication Details
- International journal of bioprinting, p1673
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Scopus ID
- 2-s2.0-85197366080
- Other Identifier
- 991021841342904721