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Increased tissue nitric oxide (NO) and cortical blood flow during functional activation of rat brain
Journal article

Increased tissue nitric oxide (NO) and cortical blood flow during functional activation of rat brain

Donald Buerk, Beau Ances, John Detre and Joel Greenberg
Proceedings of the First Joint BMES/EMBS Conference : serving humanity advancing technology, Oct. 13-16, 99, Atlanta, GA, USA, v 1, pp 366-366
01 Jan 1999

Abstract

Brain Electrochemical sensors Flow measurement Functional electric stimulation Functional neural stimulation Hemodynamics Laser applications Microsensors Nitrogen oxides Tissue
Tissue nitric oxide (NO) was measured in rat somatosensory cortex using NO-sensitive electrochemical microsensors during functional activation of the brain by electrical stimulation of the forepaw, while simultaneously measuring cortical blood flow by laser Doppler flowmetry. Measurements show a rapid increase in NO which precedes the rise in cortical blood flow, suggesting that NO plays an important role in coupling cerebral blood flow with neuronal activity.

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