Journal article
Increasing spectrotemporal sound density reveals an octave-based organization in cat primary auditory cortex
The Journal of neuroscience, v 28(36), pp 8885-8896
03 Sep 2008
PMID: 18768682
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Auditory neurons are likely adapted to process complex stimuli, such as vocalizations, which contain spectrotemporal modulations. However, basic properties of auditory neurons are often derived from tone pips presented in isolation, which lack spectrotemporal modulations. In this context, it is unclear how to deduce the functional role of auditory neurons from their tone pip-derived tuning properties. In this study, spectrotemporal receptive fields ( STRFs) were obtained from responses to multi-tone stimulus ensembles differing in their average spectrotemporal density (i.e., number of tone pips per second). STRFs for different stimulus densities were derived from multiple single-unit activity (MUA) and local field potentials (LFPs), simultaneously recorded in primary auditory cortex of cats. Consistent with earlier studies, we found that the spectral bandwidth was narrower for MUA compared with LFPs. Both neural firing rate and LFP amplitude were reduced when the density of the stimulus ensemble increased. Surprisingly, we found that increasing the spectrotemporal sound density revealed with increasing clarity an over-representation of response peaks at frequencies of similar to 3, 5, 10, and 20 kHz, in both MUA- and LFP-derived STRFs. Although the decrease in spectral bandwidth and neural activity with increasing stimulus density can likely be accounted for by forward suppression, the mechanisms underlying the over-representation of the octave-spaced response peaks are unclear. Plausibly, the over-representation may be a functional correlate of the periodic pattern of corticocortical connections observed along the tonotopic axis of cat auditory cortex.
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Details
- Title
- Increasing spectrotemporal sound density reveals an octave-based organization in cat primary auditory cortex
- Creators
- Arnaud J. Norena - Centre National de la Recherche ScientifiqueBoris Gourevitch - University of CalgaryMartin Pienkowski - University of CalgaryGreg Shaw - University of CalgaryJos J. Eggermont - University of Calgary
- Publication Details
- The Journal of neuroscience, v 28(36), pp 8885-8896
- Publisher
- Soc Neuroscience
- Number of pages
- 12
- Grant note
- Campbell McLaurin Chair for Hearing Deficiencies Alberta Heritage Foundation for Medical Research National Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada (NSERC) Canadian Institutes of Health-New Emerging Team; Canadian Institutes of Health Research (CIHR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Audiology - 4 Year
- Web of Science ID
- WOS:000258890900005
- Scopus ID
- 2-s2.0-54049131823
- Other Identifier
- 991022025116504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences