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Journal article
Independent ischemic stroke risk factors in older Americans: a systematic review
Aging (Albany, NY.), v 11(10), pp 3392-3407
24 May 2019
PMID: 31127075
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Framingham Stroke Risk Profile (FSRP) is a validated model for predicting 10-year ischemic stroke risk in middle-aged adults, yet has not been demonstrated to consistently translate in older populations. This is a systematic review of independent risk factors measured among
65 year olds, with subsequent first ischemic stroke, using PRISMA guidelines. We appraised peer-reviewed publications that included participants
65 years old at risk assessment. Combined with other criteria, results were abstracted from 28 papers reporting six types of stroke risk factors: Serologic/Diagnostic, Conventional, Psychosocial, Genetic, Cognitive, and Antibiotic use. These studies demonstrated levels of serum androgens, C-reactive protein, and advanced glycation endproducts; thrombin generation; left ventricular mass; depressive symptoms; phosphodiesterase 4D single nucleotide polymorphisms; coagulation factor XII gene; peak thrombus generation; and lower cognitive functioning were independent risk factors for ischemic stroke in older adults. Plasma adipokines, free fatty acids and antibiotic use did not predict ischemic stroke. Purpose in life and APOEε2 allele were protective for ischemic stroke. This systematic review provides evidence of risk and protective factors for ischemic stroke in older cohorts that are not included in the FSRP. Further studies are needed to understand whether these factors are important enough to comprise a risk score.
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Details
- Title
- Independent ischemic stroke risk factors in older Americans: a systematic review
- Creators
- Jonathan Singer - Department of Clinical Psychology, University of Nevada, Reno, NV 89557, USADeborah Gustafson - SUNY Downstate Health Sciences UniversityCaroline Cummings - University of Nevada, RenoAron Egelko - Kings County Hospital CenterJack Mlabasati - Drexel UniversityAlyssa Conigliaro - Hofstra UniversitySteven R Levine - State University of New York Downstate Medical Center, Department of Neurology and Stroke Center, New York City Health + Hospitals/Kings County, Brooklyn, NY 11203, USA
- Publication Details
- Aging (Albany, NY.), v 11(10), pp 3392-3407
- Grant note
- U01 HL146202 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000469944000029
- Scopus ID
- 2-s2.0-85066811433
- Other Identifier
- 991021860794804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology