Journal article
Individual-Level Concentrations of Fine Particulate Matter Chemical Components and Subclinical Atherosclerosis: A Cross-Sectional Analysis Based on 2 Advanced Exposure Prediction Models in the Multi-Ethnic Study of Atherosclerosis
American journal of epidemiology, v 180(7), pp 718-728
01 Oct 2014
PMID: 25164422
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Long-term exposure to outdoor particulate matter with an aerodynamic diameter less than or equal to 2.5 A mu m (PM2.5) has been associated with cardiovascular morbidity and mortality. The chemical composition of PM2.5 that may be most responsible for producing these associations has not been identified. We assessed cross-sectional associations between long-term concentrations of PM2.5 and 4 of its chemical components (sulfur, silicon, elemental carbon, and organic carbon (OC)) and subclinical atherosclerosis, measured as carotid intima-media thickness (CIMT) and coronary artery calcium, between 2000 and 2002 among 5,488 Multi-Ethnic Study of Atherosclerosis participants residing in 6 US metropolitan areas. Long-term concentrations of PM2.5 components at participants' homes were predicted using both city-specific spatiotemporal models and a national spatial model. The estimated differences in CIMT associated with interquartile-range increases in sulfur, silicon, and OC predictions from the spatiotemporal model were 0.022 mm (95% confidence interval (CI): 0.014, 0.031), 0.006 mm (95% CI: 0.000, 0.012), and 0.026 mm (95% CI: 0.019, 0.034), respectively. Findings were generally similar using the national spatial model predictions but were often sensitive to adjustment for city. We did not find strong evidence of associations with coronary artery calcium. Long-term concentrations of sulfur and OC, and possibly silicon, were associated with CIMT using 2 distinct exposure prediction modeling approaches.
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Details
- Title
- Individual-Level Concentrations of Fine Particulate Matter Chemical Components and Subclinical Atherosclerosis: A Cross-Sectional Analysis Based on 2 Advanced Exposure Prediction Models in the Multi-Ethnic Study of Atherosclerosis
- Creators
- Sun-Young Kim - Seoul National UniversityLianne Sheppard - University of WashingtonJoel D. Kaufman - University of WashingtonSilas Bergen - University of WashingtonAdam A. Szpiro - University of WashingtonTimothy V. Larson - University of WashingtonSara D. Adar - University of Michigan–Ann ArborAna V. Diez Roux - Drexel UniversityJoseph F. Polak - Tufts UniversitySverre Vedal - University of Washington
- Publication Details
- American journal of epidemiology, v 180(7), pp 718-728
- Publisher
- Oxford Univ Press
- Number of pages
- 11
- Grant note
- Multi-Ethnic Study of Atherosclerosis and Air Pollution R44HL095169 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) RD 831697 / Environmental Protection Agency (EPA) Science to Achieve Results (STAR) Program UL1RR024156 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) T32ES015459 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01HC095160 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) RD 83479601; CR-834077101-0 / EPA; United States Environmental Protection Agency 4749-RFA05 / National Particle Component Toxicity (NPACT) Initiative - Health Effects Institute N01-HC-95159; N01-HC-95169; UL1-RR-024156 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Multi-Ethnic Study of Atherosclerosis T32ES015459; P50 ES015915 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000343054500007
- Scopus ID
- 2-s2.0-84927767097
- Other Identifier
- 991019168465904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health