Journal article
Individual participant data meta-analysis of eating behaviour traits as effect modifiers in acceptance and commitment therapy-based weight management interventions
International journal of obesity (2005)
10 Apr 2025
PMID: 40211060
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Obesity care may benefit from precision approaches, matching patients to treatment types based on their individual characteristics, including eating behaviour traits (EBTs) like emotional eating, uncontrolled eating, external eating, internal disinhibition and restraint. Initial evidence suggests that Acceptance and Commitment Therapy (ACT)-based interventions might address dysregulated EBTs more effectively than standard behavioural treatments. However, it is unclear if ACT is more effective for certain EBT levels.
This pre-registered (CRD42022359691) one-stage Individual Participant Data (IPD) meta-analysis explored the moderating effects of baseline EBTs on weight outcomes in trials of ACT-based interventions for adults with a BMI ≥ 25 kg/m
. Unlike traditional meta-analyses, IPD meta-analyses re-analyse existing data to answer novel research questions. We identified 16 eligible trials through a systematic search of eight databases until June 20, 2022. We obtained, checked, and harmonised data from 15 trials (N = 2535). We used mixed regression models to investigate both continuous and categorical interaction effects.
We found no evidence of interactions between ACT vs. control and baseline EBTs as continuous variables on percentage weight change. However, we found evidence to suggest an added difference in weight change of -4.47% (95%CI -1.15, -7.73) from baseline to 12-months after intervention end in participants with medium levels of internal disinhibition compared to those with high levels. Sensitivity analyses similarly indicated a greater intervention benefit for participants with medium, rather than high, emotional eating levels (in trials that reduced experiential avoidance and in trials using the three-factor eating questionnaire) and internal disinhibition (in analyses of participants with at least 60% attendance). Given the exploratory nature of analyses, results should be interpreted with caution.
Findings suggest potential non-linear interaction effects of ACT with internal disinhibition but require replication in confirmatory trials. These results may help guide further research on precision approaches based on EBTs.
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Details
- Title
- Individual participant data meta-analysis of eating behaviour traits as effect modifiers in acceptance and commitment therapy-based weight management interventions
- Creators
- Laura Kudlek - MRC Epidemiology UnitPatricia Eustachio Colombo - University of CambridgeJulia Mueller - MRC Epidemiology UnitStephen J Sharp - University of CambridgeClare E Boothby - MRC Epidemiology UnitSimon J Griffin - MRC Epidemiology UnitMeghan Butryn - Drexel UniversityChristina Chwyl - Drexel UniversityEvan Forman - Drexel UniversityCharlotte Hagerman - Drexel UniversityMisty Hawkins - Indiana University BloomingtonAdrienne Juarascio - Drexel UniversityBärbel Knäuper - McGill UniversityMarjukka Kolehmainen - University of Eastern FinlandMichael E Levin - Utah State UniversityJason Lillis - Brown UniversityEdurne Maiz - University of the Basque CountryStephanie Manasse - Drexel UniversityLara Palmeira - Universidade PortucalenseKirsi H Pietiläinen - University of HelsinkiNancy E Sherwood - University of MinnesotaAmy L Ahern - MRC Epidemiology Unit
- Publication Details
- International journal of obesity (2005)
- Publisher
- Nature Publishing Group
- Number of pages
- 11
- Grant note
- Medical Research Council: MC_UU_00006/6 National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre: NIHR203312
This work was supported by the Medical Research Council MC_UU_00006/6 and by the National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre (NIHR203312) as part of the lead authors PhD. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology); WELL Center
- Web of Science ID
- WOS:001463098200001
- Scopus ID
- 2-s2.0-105002343608
- Other Identifier
- 991022047147004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics