Journal article
Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease
The Journal of experimental medicine, v 184(4), pp 1425-1433
01 Oct 1996
PMID: 8879214
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In Alzheimer's disease (AD), affected neurons accumulate beta amyloid protein, components of which can induce mouse microglia to express the high-output isoform of nitric oxide synthase (NOS2) in vitro. Products of NOS2 can be neurotoxic. In mice, NOS2 is normally suppressed by transforming growth factor beta 1 (TGF-beta 1). Expression of TGF-beta 1 is decreased in brains from AD patients, a situation that might be permissive for accumulation of NOS2. Accordingly, we investigated the expression of NOS2 in patients with AD, using three monospecific antibodies: a previously described polyclonal and two new monoclonal antibodies. Neurofibrillary tangle-bearing neurons and neuropil threads contained NOS2 in brains from each of 11 AD patients ranging in age from 47 to 81 years. NOS2 was undetectable in brains from 6 control subjects aged 23-72 years, but was expressed in small amounts in 3 control subjects aged 77-87 years. Thus, human neurons can express NOS2 in vivo. The high-output pathway of NO production may contribute to pathogenesis in AD.
Metrics
Details
- Title
- Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease
- Creators
- Y Vodovotz - National Institutes of HealthM S Lucia - National Institutes of HealthK C Flanders - National Institutes of HealthL Chesler - National Institutes of HealthQ W Xie - National Institutes of HealthT W Smith - National Institutes of HealthJ Weidner - National Institutes of HealthR Mumford - National Institutes of HealthR Webber - National Institutes of HealthC Nathan - National Institutes of HealthA B Roberts - National Institutes of HealthC F Lippa - National Institutes of HealthM B Sporn - National Institutes of Health
- Publication Details
- The Journal of experimental medicine, v 184(4), pp 1425-1433
- Publisher
- Rockefeller University Press
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:A1996VP23000025
- Scopus ID
- 2-s2.0-10244235267
- Other Identifier
- 991019312351704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental