Journal article
Induction of Interleukin-12 Production in Chronic Hepatitis C Virus Infection Correlates with the Hepatocellular Damage
The Journal of infectious diseases, v 178(1), pp 247-251
01 Jul 1998
PMID: 9652448
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Interleukin (IL)-12 plays an essential role in host defense against infectious diseases. Serum IL-12 concentration and blood mononuclear cell production with or without specific interferon (IFN)-γ priming were investigated in 65 chronic hepatitis C virus (HCV) patients and 25 healthy donors. HCV patients had higher serum IL-12 levels (P = .004) and produced higher amounts after IFN-γ priming (P < .001) than donors. A subset of patients did not produce IL-12: They had lower serum levels (P = .032) and showed signs of liver piecemeal necrosis less frequently (P = .011). Patients with greater liver necroinflammatory activity produced more IL-12 than patients with minimal or mild activity and donors (P < .01). During IFN-α therapy for 16 HCV patients, individuals with end-of-treatment alanine aminotransferase normalization and clearance of viremia had higher serum levels and produced more IL-12 than those who did not (P < .05). These results suggest a role for IL-12 in the immunopathogenesis and outcome of HCV infection.
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Details
- Title
- Induction of Interleukin-12 Production in Chronic Hepatitis C Virus Infection Correlates with the Hepatocellular Damage
- Creators
- Juan Antonio Quiroga - Hospital Universitario Fundación Jiménez DíazJulio Martín - Fundación para el Estudio de las Hepatitis ViralesSonia Navas-Martin - Drexel University, Microbiology and ImmunologyVicente Carreño - Fundación para el Estudio de las Hepatitis Virales
- Publication Details
- The Journal of infectious diseases, v 178(1), pp 247-251
- Publisher
- The University of Chicago Press
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000074357900033
- Scopus ID
- 2-s2.0-0031844841
- Other Identifier
- 991022047819604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology