Journal article
Induction of heterotypic virus resistance in adult inbred mice immunized with a variant of Coxsackievirus B3
Microbial pathogenesis, v 8(4), pp 289-298
1990
PMID: 2166894
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Infection of adult male C3H/HeJ mice with a host range variant of Coxsackievirus B3 (CB3W-RD) induced resistance in these mice to an otherwise lethal dose of Coxsackievirus B1 (CB1). The protective effect induced by CB3W-RD was detectable as early as 1 day post-vaccination and was still present 10 weeks later. While untreated mice infected with CB1 died within 5 days because of massive hepatic necrosis, the liver was spared in mice immunized with CB3W-RD and then challenged with CB1. In general, CB1 titers in heart, liver, and pancreas of CB3W-RD-vaccinated animals were lower than that found in unvaccinated animals. Virus neutralizing antibody was not a mediator of this heterotypic, virus-induced protective effect. In addition, the outcome of CB1 infection could be modified if superinfection with CB3W-RD took place within 1–4 days following CB1 infection. In this regard, maximum therapeutic efficacy was observed when CB1 infected mice were superinfected 2 days after CB1 infection. CB1-infected mice that survived as a result of treatment with CB3W-RD exhibited liver regeneration but did develop myocardial necrosis.
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Details
- Title
- Induction of heterotypic virus resistance in adult inbred mice immunized with a variant of Coxsackievirus B3
- Creators
- Burton J. Landau - Hahnemann University HospitalP.Susan Whittier - Hahnemann University HospitalSydney D. Finkelstein - Hahnemann University HospitalBarbara Alstein - Hahnemann University HospitalJanet B. Grun - Hahnemann University HospitalMaggie Schultz - Hahnemann University HospitalRichard L. Crowell - Hahnemann University Hospital
- Publication Details
- Microbial pathogenesis, v 8(4), pp 289-298
- Publisher
- Elsevier India Pvt Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:A1990DL82000005
- Scopus ID
- 2-s2.0-0025280771
- Other Identifier
- 991019183974604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Microbiology