Journal article
Induction of natural killer cell activity of thoracic duct lymphocytes by polyinosinic-polycytidylic acid (poly(I:C)) or interferon
Cellular immunology, v 91(2), pp 336-343
01 Apr 1985
PMID: 2581698
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Natural killer (NK) cell activity of thoracic duct lymphocytes (TDL) was examined in normal mice and in mice treated with polyinosinic-polycytidylic acid (poly(I:C)) and interferon (IFN). TDL from mice treated with phosphate-buffered saline (PBS) expressed little or no NK cell activity against YAC-1 target cells at effector-to-target ratios of up to 200:1, even after
in vitro treatment with murine L-cell IFN. In contrast, TDL from poly(I:C)- or IFN-treated mice expressed significant NK activity, which correlated with the significantly higher NK activity of splenocytes from these mice compared to the NK activity of splenocytes from PBS-treated mice. These data indicate that although TDL from normal mice express no detectable NK cell activity, NK cell activity can be induced in TDL by
in vivo treatment with poly(I:C) or IFN.
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Details
- Title
- Induction of natural killer cell activity of thoracic duct lymphocytes by polyinosinic-polycytidylic acid (poly(I:C)) or interferon
- Creators
- Kerin L. Fresa - Department of Microbiology and Immunology, The Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129, U.S.ARobert Korngold - The Wistar InstituteDonna M. Murasko - Department of Microbiology and Immunology, The Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129, U.S.A
- Publication Details
- Cellular immunology, v 91(2), pp 336-343
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1985AFY5600002
- Scopus ID
- 2-s2.0-0021948411
- Other Identifier
- 991020950770804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Immunology