Journal article
Infant siblings and the investigation of autism risk factors
Journal of neurodevelopmental disorders, v 4(1), pp 7-7
2012
PMID: 22958474
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Infant sibling studies have been at the vanguard of autism spectrum disorders (ASD) research over the past decade, providing important new knowledge about the earliest emerging signs of ASD and expanding our understanding of the developmental course of this complex disorder. Studies focused on siblings of children with ASD also have unrealized potential for contributing to ASD etiologic research. Moving targeted time of enrollment back from infancy toward conception creates tremendous opportunities for optimally studying risk factors and risk biomarkers during the pre-, peri- and neonatal periods. By doing so, a traditional sibling study, which already incorporates close developmental follow-up of at-risk infants through the third year of life, is essentially reconfigured as an enriched-risk pregnancy cohort study. This review considers the enriched-risk pregnancy cohort approach of studying infant siblings in the context of current thinking on ASD etiologic mechanisms. It then discusses the key features of this approach and provides a description of the design and implementation strategy of one major ASD enriched-risk pregnancy cohort study: the Early Autism Risk Longitudinal Investigation (EARLI).
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Details
- Title
- Infant siblings and the investigation of autism risk factors
- Creators
- Craig J Newschaffer - Department of Epidemiology and Biostatistics, Drexel School of Public Health, 1505 Race Street, Mail Stop 1033, Philadelphia, PA 19102, USALisa A Croen - Kaiser Permanente Division of Research, 2000 Broadway, Oakland, CA 94612, USAM Daniele Fallin - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USAIrva Hertz-Picciotto - Department of Public Health Sciences, University of California, Davis, CA 95616, USADanh V Nguyen - Department of Public Health Sciences, University of California, Davis, CA 95616, USANora L Lee - Department of Epidemiology and Biostatistics, Drexel School of Public Health, 1505 Race Street, Mail Stop 1033, Philadelphia, PA 19102, USACarmen A Berry - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USAHomayoon Farzadegan - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USAH Nicole Hess - Kaiser Permanente San Jose Medical Center, 6620 Via Del Oro, San Jose, CA 95119, USARebecca J Landa - Kennedy Krieger Institute, 3901 Greenspring Avenue, 2nd Floor, Baltimore, MD 21211, USASusan E Levy - Center for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 860, Philadelphia, PA 19104, USAMaria L Massolo - Kaiser Permanente Division of Research, 2000 Broadway, Oakland, CA 94612, USAStacey C Meyerer - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USASandra M Mohammed - Department of Public Health Sciences, University of California, Davis, CA 95616, USAMcKenzie C Oliver - Department of Public Health Sciences, University of California, Davis, CA 95616, USASally Ozonoff - The MIND Institute, UC Davis Medical Center, 2825 50th Street, Sacramento, CA 95817, USAJuhi Pandey - Center for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 860, Philadelphia, PA 19104, USAAdam Schroeder - Department of Public Health Sciences, University of California, Davis, CA 95616, USAKristine M Shedd-Wise - Department of Public Health Sciences, University of California, Davis, CA 95616, USA
- Publication Details
- Journal of neurodevelopmental disorders, v 4(1), pp 7-7
- Publisher
- BioMed Central
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000310501800001
- Scopus ID
- 2-s2.0-84863973562
- Other Identifier
- 991014877702404721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences