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Infants Born to Mothers with Clinical Chorioamnionitis: A Cross-Sectional Survey on the Use of Early-Onset Sepsis Risk Calculator and Prolonged Use of Antibiotics
Journal article   Open access   Peer reviewed

Infants Born to Mothers with Clinical Chorioamnionitis: A Cross-Sectional Survey on the Use of Early-Onset Sepsis Risk Calculator and Prolonged Use of Antibiotics

Marina Ayrapetyan, David Carola, Satyan Lakshminrusimha, Vineet Bhandari and Zubair H Aghai
American journal of perinatology, v 36(4), pp 428-433
Mar 2019
DOI: https://doi.org/10.1055/s-0038-1668548
PMID: 30130819
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631007View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Anti-Bacterial Agents - therapeutic use Antimicrobial Stewardship Asymptomatic Infections Blood Cell Count C-Reactive Protein - analysis Chorioamnionitis Cross-Sectional Studies Female Guideline Adherence Health Care Surveys Humans Infant, Newborn Neonatal Sepsis - diagnosis Neonatal Sepsis - drug therapy Neonatal Sepsis - prevention & control Practice Guidelines as Topic Pregnancy Prospective Studies Risk Assessment
To evaluate variations in practice for the management of neonates born to mothers with clinical chorioamnionitis. This was a prospective cross-sectional survey consisting of 10 multiple choice questionnaires distributed to 2,900 members of the Perinatal Section of American Academy of Pediatrics. Variations in responses were assessed and compared between the various groups. A total of 682 members (23.5%) completed the survey; 169 (24.8%) indicated that they use the neonatal early-onset sepsis (EOS) risk calculator for the management of neonates born to mothers with clinical chorioamnionitis. More respondents from the western region of United States and level III units are using the EOS risk calculator compared with the south and level II units. Approximately 44% of the respondents indicated that they will not stop antibiotics at 48 to 72 hours in asymptomatic neonates born to mothers with chorioamnionitis with negative blood culture if the complete blood count (CBC) and C-reactive protein (CRP) are abnormal. A large number of practitioners are using the neonatal EOS risk calculator for neonates born to mothers with chorioamnionitis. Despite a clear guideline from the Committee on Fetus and Newborn, almost 44% will treat healthy-appearing neonates born to mothers with chorioamnionitis with a prolonged course of antibiotics solely for abnormal CBC or CRP.

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18 citations in Web of Science
19 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Obstetrics & Gynecology
Pediatrics
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